Glutamatergic Signaling in the Central Nervous System: Ionotropic and Metabotropic Receptors in Concert

被引:408
作者
Reiner, Andreas [1 ]
Levitz, Joshua [2 ]
机构
[1] Ruhr Univ Bochum, Dept Biol & Biotechnol, Bochum, Germany
[2] Weill Cornell Med, Dept Biochem, New York, NY 10065 USA
关键词
LONG-TERM DEPRESSION; EXCITATORY SYNAPTIC-TRANSMISSION; PROTEIN-KINASE-II; AMPA RECEPTOR; NMDA RECEPTORS; ENDOPLASMIC-RETICULUM; KAINATE RECEPTORS; STRUCTURAL BASIS; FRAGILE-X; NEUROTRANSMITTER RELEASE;
D O I
10.1016/j.neuron.2018.05.018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as a key neuromodulator to control synapse and circuit function over a wide range of spatial and temporal scales. This functional diversity is decoded by two receptor families: ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The challenges posed by the complexity and physiological importance of each of these subtypes has limited our appreciation and understanding of how these receptors work in concert. In this review, by comparing both receptor families with a focus on their crosstalk, we argue for a more holistic understanding of neural glutamate signaling.
引用
收藏
页码:1080 / 1098
页数:19
相关论文
共 271 条
  • [91] Activation of the phosphoinositide 3-kinase-akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
    Hou, LF
    Klann, E
    [J]. JOURNAL OF NEUROSCIENCE, 2004, 24 (28) : 6352 - 6361
  • [92] Homeostatic Regulation of AMPA Receptor Trafficking and Degradation by Light-Controlled Single-Synaptic Activation
    Hou, Qingming
    Gilbert, James
    Man, Heng-Ye
    [J]. NEURON, 2011, 72 (05) : 806 - 818
  • [93] Glutamate Stimulates Local Protein Synthesis in the Axons of Rat Cortical Neurons by Activating α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors and Metabotropic Glutamate Receptors
    Hsu, Wei-Lun
    Chung, Hui-Wen
    Wu, Chih-Yueh
    Wu, Huei-Ing
    Lee, Yu-Tao
    Chen, En-Chan
    Fang, Weilun
    Chang, Yen-Chung
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (34) : 20748 - 20760
  • [94] Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression
    Huber, KM
    Kayser, MS
    Bear, MF
    [J]. SCIENCE, 2000, 288 (5469) : 1254 - 1256
  • [95] Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression
    Hughes, Z. A.
    Neal, S. J.
    Smith, D. L.
    Rizzo, S. J. Sukoff
    Pulicicchio, C. M.
    Lotarski, S.
    Lu, S.
    Dwyer, J. M.
    Brennan, J.
    Olsen, M.
    Bender, C. N.
    Kouranova, E.
    Andree, T. H.
    Harrison, J. E.
    Whiteside, G. T.
    Springer, D.
    O'Neil, S. V.
    Leonard, S. K.
    Schechter, L. E.
    Dunlop, J.
    Rosenzweig-Lipson, S.
    Ring, R. H.
    [J]. NEUROPHARMACOLOGY, 2013, 66 : 202 - 214
  • [96] Synaptic plasticity of NMDA receptors: mechanisms and functional implications
    Hunt, David L.
    Castillo, Pablo E.
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2012, 22 (03) : 496 - 508
  • [97] Efficient, Complete Deletion of Synaptic Proteins using CRISPR
    Incontro, Salvatore
    Asensio, Cedric S.
    Edwards, Robert H.
    Nicoll, Roger A.
    [J]. NEURON, 2014, 83 (05) : 1051 - 1057
  • [98] Phosphorylation and Feedback Regulation of Metabotropic Glutamate Receptor 1 by Calcium/Calmodulin-Dependent Protein Kinase II
    Jin, Dao-Zhong
    Guo, Ming-Lei
    Xue, Bing
    Fibuch, Eugene E.
    Choe, Eun Sang
    Mao, Li-Min
    Wang, John Q.
    [J]. JOURNAL OF NEUROSCIENCE, 2013, 33 (08) : 3402 - 3412
  • [99] mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks
    Jin, Lu E.
    Wang, Min
    Galvin, Veronica C.
    Lightbourne, Taber C.
    Conn, Peter Jeffrey
    Arnsten, Amy F. T.
    Paspalas, Constantinos D.
    [J]. CEREBRAL CORTEX, 2018, 28 (03) : 974 - 987
  • [100] Crystal structure and association behaviour of the GluR2 amino-terminal domain
    Jin, Rongsheng
    Singh, Satinder K.
    Gu, Shenyan
    Furukawa, Hiroyasu
    Sobolevsky, Alexander I.
    Zhou, Jie
    Jin, Yan
    Gouaux, Eric
    [J]. EMBO JOURNAL, 2009, 28 (12) : 1812 - 1823