Effect of cholera toxin on intestinal elimination of ciprofloxacin in rabbits

被引：0

作者：

Musafija, A

Barzilai, A

Ramon, J

Rubinstein, E ^{[1
]}

机构：

[1] Tel Aviv Univ, Chaim Sheba Med Ctr, Sch Med, Infect Dis Unit, IL-52621 Tel Hashomer, Israel

[2] Tel Aviv Univ, Chaim Sheba Med Ctr, Sch Med, Dept Urol, IL-52621 Tel Hashomer, Israel

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 02期

关键词：

D O I：

暂无

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The transepithelial intestinal elimination of ciprofloxacin (CPX) was studied in cholera toxin (CT)-challenged and control intestinal loops in the rabbit. CPX concentrations were similar in CT-challenged and control jejunal and ileal loops, while cecal elimination was negligible. The quantities of eliminated CPX per square centimeter of bowel wall were significantly higher in the small intestine CT-challenged loops. The mechanism of elimination of CPX in the small intestine is therefore mainly passive diffusion.

引用

页码：473 / 474

页数：2

共 8 条

[1] INTESTINAL FLUID AND ELECTROLYTE TRANSPORT IN HUMAN CHOLERA [J].