Cutoff value of urinary arginine vasopressin for nocturnal polyuria in elderly men

被引：10

作者：

Akiyama, Tatsuya ^{[1
]}

Hirayama, Akihide ^{[1
]}

Fujimoto, Kiyohide ^{[1
]}

Torimoto, Kazumasa ^{[1
]}

Yoshida, Kastunori ^{[1
]}

Hirao, Yoshihiko ^{[1
]}

机构：

[1] Nara Med Univ, Dept Urol, Kashihara, Nara 6348522, Japan

来源：

UROLOGY | 2007年 / 69卷 / 01期

关键词：

D O I：

10.1016/j.urology.2006.09.037

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVES To determine the cutoff value of early-morning urinary arginine vasopressin (uAVP)/urinary creatinine (uCr) for patients with nocturnal polyuria (NP), and to investigate whether abnormal secretion of AVP at nighttime is a risk factor of NP in elderly men. METHODS A total of 189 men older than 50 years of age with nocturia were enrolled. The frequency volume chart a was recorded. The UAVP, urinary sodium, uCr, and osmolarity of a single urine sample voided at 6:00 AM were measured in all cases. Two definitions of NP-nocturnal urine volume/ 24-hr production greater than 0.35 (NP index [NPI] definition) and a nocturnal urine volume of 0.9 mL/min X the sleeping duration or greater (NUV definition)-were used for analysis. RESULTS uAVP/uCr was an independent predictor for NP according to the NPI and NUV definitions. The cutoff value of uAVP/uCr for NP was 23.4 pg/mL/Cr according to the NPI definition and 28.3 pg/mL/Cr according to the NUV definition. The sensitivity of the cutoff value according to the NPI and NUV definitions was 69% and 77%, respectively, and the specificity was 61% and 66%, respectively. In both NP definitions, 31% and 38% of the patients with a uAVP/uCr greater than the cutoff value showed NP. Significant differences in NUV and urine osmolarity, but not in uAvp/uCr and uNa/uCr, between the NP group and the non-NP group were found using both NP definitions. CONCLUSIONS We demonstrated that age and uAVP/uCr were independent predictive factors for nocturia in patients with NP. The cutoff value of uAVP/uCr is a useful screening marker for NP in elderly men with nocturia. (c) 2007 Elsevier Inc.

引用

页码：98 / 102

页数：5

共 14 条

[11] Renal regulation of urine volume: potential implications for nocturia [J].

Robertson, GL ;

Norgaard, JP .

BJU INTERNATIONAL, 2002, 90 :7-10

[12] INFLUENCE OF AGE ON RENAL RESPONSE TO WATER-DEPRIVATION IN MAN [J].

ROWE, JW ;

SHOCK, NW ;

DEFRONZO, RA .

NEPHRON, 1976, 17 (04) :270-278

[13] The standardisation of terminology in nocturia: Report from the standardisation sub-committee of the International Continence Society [J].

van Kerrebroeck, P ;

Abrams, P ;

Chaikin, D ;

Donovan, J ;

Fonda, D ;

Jackson, S ;

Jennum, P ;

Johnson, T ;

Lose, G ;

Mattiasson, A ;

Robertson, G ;

Weiss, J .

NEUROUROLOGY AND URODYNAMICS, 2002, 21 (02) :179-183

[14] Nocturia [J].

Weiss, JP ;

Blaivas, JG .

JOURNAL OF UROLOGY, 2000, 163 (01) :5-12

← 1 2 →