Signaling pathway(s) of TNFR2 required for the immunoregulatory effect of CD4+Foxp3+ regulatory T cells

被引：15

作者：

He, Tianzhen ^{[1
]}

Zhao, Yi ^{[2
]}

Zhao, Peng ^{[3
,4
]}

Zhao, Liwen ^{[1
]}

Zakaria, Jaffry ^{[4
]}

Wang, Ke ^{[5
]}

机构：

[1] Nantong Univ, Inst special Environm Med, Nantong 226019, Peoples R China

[2] Nantong First Peoples Hosp, Geriatr Dept, Nantong 226001, Jiangsu, Peoples R China

[3] Duke Kunshan Univ, Athlet Dept, Kunshan 215316, Jiangsu, Peoples R China

[4] Univ Pendidikan Sultan Idris, Fac Sport Sci & Coaching, Tanjong Malim 35900, Perak, Malaysia

[5] Qingdao Univ, Affiliated Hosp Qingdao Univ, Dept Urol, Dept Urol, 16 Jiangsu Rd, Shinan Dist, Qingdao 266000, Shandong, Peoples R China

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 108卷

基金：

中国国家自然科学基金;

关键词：

Tregs; TNF; TNFR2; Signaling pathway; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; MAP KINASE P38; PROTEIN-KINASE; RECEPTOR; SUPPRESSIVE FUNCTION; CUTTING EDGE; TRANSCRIPTION FACTORS; IKK-ALPHA; DIFFERENTIATION;

D O I：

10.1016/j.intimp.2022.108823

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4+Foxp3+ regulatory T cells (Tregs), a subpopulation of CD4+ T cells, are engaged in maintaining the periphery tolerance and preventing autoimmunity. Recent studies showed that tumor necrosis factor receptor 2 (TNFR2) is preferentially expressed by Tregs and the expression of this receptor identifies the maximally suppressive Tregs. That is, TNFR2 is a liable phenotypic and functional surface marker of Tregs. Moreover, TNF activates and expands Tregs through TNFR2. However, it is very interesting which signaling pathway(s) of TNFR2 is required for the inhibitory effect of Tregs. Compelling evidence shows three TNFR2 signaling pathways in Tregs, including NF-KB, MAPK and PI3K-Akt pathways. Here, we summarize and discuss the latest progress in the studies on the downstream signaling pathways of TNF-TNFR2 for controlling Treg homeostasis, differentiation and proliferation.

引用

页数：9

共 150 条

[1] Acquisition of regulatory function by human CD8+ T cells treated with anti-CD3 antibody requires TNF [J].

Ablamunits, Vitaly ;

Bisikirska, Brygida ;

Herold, Kevan C. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2010, 40 (10) :2891-2901

[2] MAP kinase p38 and its relation to T cell anergy and suppressor function of regulatory T cells [J].

Adler, Henric S. ;

Steinbrink, Kerstin .

CELL CYCLE, 2008, 7 (02) :169-175

[3] Activation of MAP kinase p38 is critical for the cell-cycle-controlled suppressor function of regulatory T cells [J].

Adler, Henric S. ;

Kubsch, Sebastian ;

Graulich, Edith ;

Ludwig, Stephan ;

Knop, Juergen ;

Steinbrink, Kerstin .

BLOOD, 2007, 109 (10) :4351-4359

[4] The Key Role of TNF-TNFR2 Interactions in the Modulation of Allergic Inflammation: A Review [J].

Ahmad, Suhana ;

Azid, Nor Azrini ;

Boer, Jennifer C. ;

Lim, JitKang ;

Chen, Xin ;

Plebanski, Magdalena ;

Mohamud, Rohimah .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[5] Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha [J].

Alessi, DR ;

James, SR ;

Downes, CP ;

Holmes, AB ;

Gaffney, PRJ ;

Reese, CB ;

Cohen, P .

CURRENT BIOLOGY, 1997, 7 (04) :261-269

[6] Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity [J].

Atretkhany, Kamar-Sulu N. ;

Mufazalov, Ilgiz A. ;

Dunst, Josefine ;

Kuchmiy, Anna ;

Gogoleva, Violetta S. ;

Andruszewski, David ;

Drutskaya, Marina S. ;

Faustman, Denise L. ;

Schwabenland, Marius ;

Prinz, Marco ;

Kruglov, Andrey A. ;

Waisman, Ari ;

Nedospasov, Sergei A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (51) :13051-13056

[7] Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context [J].

Baeyens, Audrey ;

Saadoun, David ;

Billiard, Fabienne ;

Rouers, Angeline ;

Gregoire, Sylvie ;

Zaragoza, Bruno ;

Grinberg-Bleyer, Yenkel ;

Marodon, Gilles ;

Piaggio, Eliane ;

Salomon, Benoit L. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (03) :999-1010

[8]

Ban Liqin, 2015, Mol Cell Ther, V3, P7

[9] TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties [J].

Beldi, Ghada ;

Bahiraii, Sheyda ;

Lezin, Chloe ;

Barkestani, Mahsa Nouri ;

Abdelgawad, Mohamed Essameldin ;

Uzan, Georges ;

Naserian, Sina .

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8

[10] TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function [J].

Beldi, Ghada ;

Khosravi, Maryam ;

Abdelgawad, Mohamed Essameldin ;

Salomon, Benoit L. ;

Uzan, Georges ;

Haouas, Houda ;

Naserian, Sina .

STEM CELL RESEARCH & THERAPY, 2020, 11 (01)

← 1 2 3 4 5 6 7 8 9 10 →