A genome-wide association study of marginal zone lymphoma shows association to the HLA region

被引：48

作者：

Vijai, Joseph ^{[1
]}

Wang, Zhaoming ^{[2
]}

Berndt, Sonja I. ^{[3
]}

Skibola, Christine F. ^{[4
,5
]}

Slager, Susan L. ^{[6
]}

de Sanjose, Silvia ^{[7
,8
]}

Melbye, Mads ^{[9
,10
]}

Glimelius, Bengt ^{[11
,12
]}

Bracci, Paige M. ^{[13
]}

Conde, Lucia ^{[4
,5
]}

Birmann, Brenda M. ^{[14
,15
]}

Wang, Sophia S. ^{[16
]}

Brooks-Wilson, Angela R. ^{[17
,18
]}

Lan, Qing ^{[3
]}

de Bakker, Paul I. W. ^{[19
,20
]}

Vermeulen, Roel C. H. ^{[20
,21
]}

Portlock, Carol ^{[1
]}

Ansell, Stephen M. ^{[22
]}

Link, Brian K. ^{[23
]}

Riby, Jacques ^{[4
,5
]}

North, Kari E. ^{[24
,25
]}

Gu, Jian ^{[26
]}

Hjalgrim, Henrik ^{[9
]}

Cozen, Wendy ^{[27
,28
]}

Becker, Nikolaus ^{[29
]}

Teras, Lauren R. ^{[30
]}

Spinelli, John J. ^{[31
,32
]}

Turner, Jenny ^{[33
,34
]}

Zhang, Yawei ^{[35
]}

Purdue, Mark P. ^{[3
]}

Giles, Graham G. ^{[36
,37
]}

Kelly, Rachel S. ^{[38
]}

Zeleniuch-Jacquotte, Anne ^{[39
,40
]}

Ennas, Maria Grazia ^{[41
]}

Monnereau, Alain ^{[42
,43
,44
]}

Bertrand, Kimberly A. ^{[14
,15
,45
]}

Albanes, Demetrius ^{[3
]}

Lightfoot, Tracy ^{[46
]}

Yeager, Meredith ^{[2
]}

Chung, Charles C. ^{[3
]}

Burdett, Laurie ^{[2
]}

Hutchinson, Amy ^{[2
]}

Lawrence, Charles ^{[47
]}

Montalvan, Rebecca ^{[47
]}

Liang, Liming ^{[45
,48
]}

Huang, Jinyan ^{[45
]}

Ma, Baoshan ^{[45
,49
]}

Villano, Danylo J. ^{[1
]}

Maria, Ann ^{[1
]}

Corines, Marina ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA

[2] NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD 20877 USA

[3] NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA

[4] Sch Publ Hlth & Comprehens Canc Ctr, Dept Epidemiol, Birmingham, AL 35233 USA

[5] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA

[6] Mayo Clin, Dept Hlth Sci, Rochester, MN 55905 USA

[7] IDIBELL, Inst Catala Oncol, Canc Epidemiol Res Programme, Unit Infect & Canc UNIC, Barcelona 8907, Spain

[8] CIBERESP, Barcelona 8036, Spain

[9] State Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, Copenhagen 2300, Denmark

[10] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[11] Karolinska Univ Hosp Solna, Karolinska Inst, Dept Pathol & Oncol, S-17176 Stockholm, Sweden

[12] Uppsala Univ, Dept Radiol Oncol & Radiat Sci, S-75105 Uppsala, Sweden

[13] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA

[14] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[15] Harvard Univ, Sch Med, Boston, MA USA

[16] City Hope Beckman Res Inst, Dept Canc Etiol, Duarte, CA 91030 USA

[17] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 1L3, Canada

[18] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 156, Canada

[19] Univ Med Ctr Utrecht, Ctr Mol Med, Dept Med Genet, NL-3584 CG Utrecht, Netherlands

[20] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, NL-3584 CX Utrecht, Netherlands

[21] Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands

[22] Mayo Clin, Dept Med, Rochester, MN 55905 USA

[23] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[24] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA

[25] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

[26] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[27] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA

[28] Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[29] German Canc Res Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[30] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA

[31] British Columbia Canc Agcy, Canc Control Res, Vancouver, BC V5Z 1L3, Canada

[32] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada

[33] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW 2109, Australia

[34] Douglass Hanly Moir Pathol, Dept Histopathol, Macquarie Park, NSW 2113, Australia

[35] Yale Univ, Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT 06520 USA

[36] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3053, Australia

[37] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic 3010, Australia

[38] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC PHE Ctr Environm & Hlth, London W2 1PG, England

[39] NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA

[40] NYU, Sch Med, Inst Canc, New York, NY 10016 USA

[41] Univ Cagliari, Dept Biomed Sci, I-09042 Cagliari, Italy

[42] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Environm Epidemiol Canc Grp, U1018, F-94807 Villejuif, France

[43] Univ Paris Sud, UMRS 1018, F-94807 Villejuif, France

[44] Inst Bergonie, Registre Hemopath Malignes Gironde, F-33076 Bordeaux, France

[45] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[46] Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England

[47] Hlth Studies Sect, Rockville, MD 20850 USA

[48] Harvard Univ, Sch Med, Dept Biostat, Boston, MA 02115 USA

[49] Dalian Maritime Univ, Coll Informat Sci & Technol, Dalian 116026, Peoples R China

[50] Mem Sloan Kettering Canc Ctr, Dept Lab Med & Pathol, New York, NY 10065 USA

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

基金：

英国医学研究理事会; 美国国家卫生研究院; 澳大利亚国家健康与医学研究理事会;

关键词：

EPIDEMIOLOGIC RESEARCH; SUSCEPTIBILITY LOCI; FOLLICULAR LYMPHOMA; CELL DEVELOPMENT; RISK LOCI; GENE; CLASSIFICATION; EXPRESSION; NEOPLASMS; VARIANTS;

D O I：

10.1038/ncomms6751

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.

引用

页数：7

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