Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress

被引:49
作者
Adachi, Taiji [1 ,2 ]
Kameo, Yoshitaka [1 ,2 ]
Hojo, Masaki [1 ]
机构
[1] Kyoto Univ, Dept Mech Engn & Sci, Sakyo Ku, Kyoto 6068501, Japan
[2] RIKEN, Computat Cell Biomech Team, VCAD Syst Res Program, Wako, Saitama 3510198, Japan
来源
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2010年 / 368卷 / 1920期
关键词
bone remodelling; functional adaptation; osteocytes; trabecular bone; computational biomechanics; CANCELLOUS BONE; CALCIUM RESPONSE; FLOW; ADAPTATION; MODEL; STRAIN; PERMEABILITY; MAINTENANCE; CANDIDATES; MICROSCOPY;
D O I
10.1098/rsta.2010.0073
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells through the intercellular communication network. In this study, bone remodelling is assumed to be regulated by the mechanical signals collected by the osteocytes. From the viewpoint of multi-scale biomechanics, we propose a mathematical model of trabecular bone remodelling that takes into account the osteocytic mechanosensory network system. Based on this model, a computational simulation of trabecular bone remodelling was conducted for a single trabecula under cyclic uniaxial loading, demonstrating functional adaptation to the applied mechanical loading as a load-bearing construct.
引用
收藏
页码:2669 / 2682
页数:14
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