Three Preparation Methods for Monodispersed Chitosan Microspheres Using the Shirasu Porous Glass Membrane Emulsification Technique and Mechanisms of Microsphere Formation

被引：26

作者：

Akamatsu, Kazuki ^{[1
]}

Kaneko, Daisaku ^{[1
]}

Sugawara, Takashi ^{[1
]}

Kikuchi, Ryuji ^{[1
]}

Nakao, Shin-ichi ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem Syst Engn, Bunkyo Ku, Tokyo 1138656, Japan

来源：

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH | 2010年 / 49卷 / 07期

关键词：

POLY(ACRYLAMIDE/METHACRYLIC ACID) MICROSPHERES; POLYMER PARTICLES; MULTIPLE EMULSIONS; MICROCHANNEL EMULSIFICATION; CONTROLLED-RELEASE; HOLLOW STRUCTURE; DRUG-DELIVERY; MICROPARTICLES; MICROCAPSULES; ETHANOL;

D O I：

10.1021/ie901821s

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The Shirasu porous glass (SPG) membrane emulsification technique was employed for the preparation of monodispersecl chitosan microspheres with the diameter controlled to be in the range from submicrometers to 10 mu m. Three preparation methods were used in this study: (1) a cross-linking method with glutaraldehyde, (2) an interaction method with alginate, and (3) a drying-in-liquid method with aqueous sodium hydroxide medium. In every preparation method, various SPG membranes with different pore sizes were used for microsphere formation, and the fabrication mechanism for the microspheres was elucidated. It was successfully shown from these detailed investigations that the average diameters of the chitosan microspheres were controlled in the range of submicrometer to 10 mu m by the pore sizes of the SPG membranes for preparing chitosan emulsions by method 1, alginate emulsions by method 2, or chitosan emulsions by method 3.

引用

页码：3236 / 3241

页数：6

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