The modular structure of actin-regulatory proteins

被引：112

作者：

Puius, YA ^{[1
]}

Mahoney, NM ^{[1
]}

Almo, SC ^{[1
]}

机构：

[1] Yeshiva Univ Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0955-0674(98)80083-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Filamentous actin structures possess unique biophysical and biochemical properties and are required for cell locomotion, cell division, compartmentalization and morphological processes. The site-specific assembly and disassembly of these structures are directed by actin-regulatory proteins. This article reviews how structural studies are now defining the atomic details of small modular domains present in actin-regulatory proteins responsible for crosslinking, severing and capping of actin filaments, as well as for localization of actin filament assembly. These studies have identified three modular strategies for the design of proteins that regulate the actin cytoskeleton.

引用

页码：23 / 34

页数：12

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