Low expression of CD200 predicts shorter time-to-treatment in chronic lymphocytic leukemia

被引:16
作者
Miao, Yi [1 ]
Fan, Lei [1 ]
Wu, Yu-Jie [1 ]
Xia, Yi [1 ]
Qiao, Chun [1 ]
Wang, Yan [1 ]
Wang, Li [1 ]
Hong, Min [1 ]
Zhu, Hua-Yuan [1 ]
Xu, Wei [1 ]
Li, Jian-Yong [1 ,2 ]
机构
[1] Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Nanjing 210029, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
CD200; mean fluorescence intensity; chronic lymphocytic leukemia; prognosis; time to treatment; VARIABLE-REGION MUTATIONS; B-CELL NEOPLASMS; PROGNOSTIC-SIGNIFICANCE; DIFFERENTIAL-DIAGNOSIS; CD38; EXPRESSION; IMMUNITY; CHINESE; SURFACE;
D O I
10.18632/oncotarget.6948
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CD200, formerly known as OX-2, is a type I glycoprotein that is expressed on a variety of cell types. CD200 has been shown to be overexpressed in chronic lymphocytic leukemia (CLL). Although previous studies have confirmed the diagnostic value of CD200 in differentiating CLL from to other B-cell chronic lymphoproliferative disorders especially mantle cell lymphoma, whether CD200 has prognostic significance in CLL remains to be determined. We evaluated the mean fluorescence intensity (MFI) of CD200 in 307 consecutive, untreated patients with CLL in our center using flow cytometry. Using a CD200 MFI cutoff of 189.5, these cases could be divided into two groups. Patients with lower CD200 MFI (< 189.5) had a significantly shorter time-to-treatment (TTT) than those with higher CD200 MFI (>= 189.5) (median TTT: 2 months vs 28 months, p = 0.0008). However, the effect of CD200 MFI on overall survival was not significant (CD200 MFI < 189.5: undefined vs CD200 MFI = 189.5: undefined, P = 0.2379). In subgroup analysis, CD200 MFI retained its prognostic value in patients with favourable characteristics such as Binet stage A disease, mutated IGHV status, normal TP53 or negative CD38 expression. In conclusion, our study identified CD200 MFI as a potential prognostic factor in CLL.
引用
收藏
页码:13551 / 13562
页数:12
相关论文
共 27 条
[1]   Diagnostic Usefulness and Prognostic Impact of CD200 Expression in Lymphoid Malignancies and Plasma Cell Myeloma [J].
Alapat, Daisy ;
Coviello-Malle, Jean ;
Owens, Rebecca ;
Qu, Pingping ;
Barlogie, Bart ;
Shaughnessy, John D. ;
Lorsbach, Robert B. .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2012, 137 (01) :93-100
[2]  
[Anonymous], LEUKEMIA LYMPHOMA
[3]   CD200 and membrane protein E interactions in the control of myeloid cells [J].
Barclay, AN ;
Wright, GJ ;
Brooke, G ;
Brown, MH .
TRENDS IN IMMUNOLOGY, 2002, 23 (06) :285-290
[4]   CD200/OX2, a cell surface molecule with immuno-regulatory function, is consistently expressed on hairy cell leukaemia neoplastic cells [J].
Brunetti, Lorenzo ;
Di Noto, Rosa ;
Abate, Giovanna ;
Gorrese, Marisa ;
Gravetti, Angela ;
Raia, Maddalena ;
Scalia, Giulia ;
Pascariello, Caterina ;
Camera, Andrea ;
Del Vecchio, Luigi .
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 145 (05) :665-667
[5]   Differential Expression of CD200 in B-Cell Neoplasms by Flow Cytometry Can Assist in Diagnosis, Subclassification, and Bone Marrow Staging [J].
Challagundla, Pramoda ;
Medeiros, Jeffrey ;
Kanagal-Shamanna, Rashmi ;
Miranda, Roberto N. ;
Jorgensen, Jeffrey L. .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2014, 142 (06) :837-844
[6]   ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia [J].
Crespo, M ;
Bosch, F ;
Villamor, N ;
Bellosillo, B ;
Colomer, D ;
Rozman, M ;
Marcé, S ;
López-Guillermo, A ;
Campo, E ;
Montserrat, E .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (18) :1764-1775
[7]   Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia [J].
Damle, RN ;
Wasil, T ;
Fais, F ;
Ghiotto, F ;
Valetto, A ;
Allen, SL ;
Buchbinder, A ;
Budman, D ;
Dittmar, K ;
Kolitz, J ;
Lichtman, SM ;
Schulman, P ;
Vinciguerra, VP ;
Rai, KR ;
Ferrarini, M ;
Chiorazzi, N .
BLOOD, 1999, 94 (06) :1840-1847
[8]   The prognostic significance of TP53 mutations in Chinese patients with chronic lymphocytic leukemia is independent of del(17p13) [J].
Dong, Hua-Jie ;
Zhou, Li-Tao ;
Zhu, Dan-Xia ;
Wang, Dong-Mei ;
Fang, Cheng ;
Zhu, Hua-Yuan ;
Zhuang, Yun ;
Miao, Kou-Rong ;
Xu, Wei ;
Li, Jian-Yong .
ANNALS OF HEMATOLOGY, 2011, 90 (06) :709-717
[9]   Diagnostic and prognostic significance of CD200 expression and its stability in plasma cell myeloma [J].
Douds, Jonathan J. ;
Long, Daniel J. ;
Kim, Annette S. ;
Li, Shaoying .
JOURNAL OF CLINICAL PATHOLOGY, 2014, 67 (09) :792-796
[10]  
El Desoukey NA, 2012, J INVEST MED, V60, P56, DOI 10.2310/JIM.0b013e31823908f9