Focus on cutaneous and uveal melanoma specificities

被引：85

作者：

Pandiani, Charlotte ^{[1
]}

Beranger, Guillaume E. ^{[1
]}

Leclerc, Justine ^{[1
]}

Ballotti, Robert ^{[1
]}

Bertolotto, Corine ^{[1
]}

机构：

[1] Univ Cote Azur, INSERM, U1065, Ctr Mediterraneen Med Mol, F-06200 Nice, France

来源：

GENES & DEVELOPMENT | 2017年 / 31卷 / 08期

关键词：

cancer; melanoma; skin; MICROPHTHALMIA TRANSCRIPTION FACTOR; GENE-EXPRESSION PROFILE; MITF GERMLINE MUTATION; OCULAR MELANOMA; SF3B1; MUTATIONS; SOMATIC MUTATIONS; DNA-DAMAGE; CONJUNCTIVAL MELANOMA; P16(INK4A) EXPRESSION; METASTATIC MELANOMA;

D O I：

10.1101/gad.296962.117

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cutaneous melanoma (CM) and uveal melanoma (UM) derive from cutaneous and uveal melanocytes that share the same embryonic origin and display the same cellular function. However, the etiopathogenesis and biological behaviors of these melanomas are very different. CM and UM display distinct landscapes of genetic alterations and show different metastatic routes and tropisms. Hence, therapeutic improvements achieved in the last few years for the treatment of CM have failed to ameliorate the clinical outcomes of patients with UM. The scope of this review is to discuss the differences in tumorigenic processes (etiologic factors and genetic alterations) and tumor biology (gene expression and signaling pathways) between CM and UM. We develop hypotheses to explain these differences, which might provide important clues for research avenues and the identification of actionable vulnerabilities suitable for the development of new therapeutic strategies for metastatic UM.

引用

页码：724 / 743

页数：20

共 230 条

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