Immune cells fold and damage fungal hyphae

被引：38
作者：
Bain, Judith M. [1 ]
Alonso, M. Fernanda [1 ,8 ]
Childers, Delma S. [1 ]
Walls, Catriona A. [1 ]
Mackenzie, Kevin [2 ]
Pradhan, Arnab [1 ,3 ]
Lewis, Leanne E. [1 ]
Louw, Johanna [1 ]
Avelar, Gabriela M. [1 ,9 ]
Larcombe, Daniel E. [1 ,3 ]
Netea, Mihai G. [4 ,5 ,6 ]
Gow, Neil A. R. [1 ,3 ]
Brown, Gordon D. [1 ,3 ]
Erwig, Lars P. [1 ,7 ]
Brown, Alistair J. P. [1 ,3 ]
机构：
[1] Inst Med Sci, Aberdeen Fungal Grp, Foresterhill, Aberdeen AB25 2ZD, Scotland
[2] Inst Med Sci, Microscopy & Histol Facil, Foresterhill, Aberdeen AB25 2ZD, Scotland
[3] Univ Exeter, Med Res Council Ctr Med Mycol, Exeter EX4 4QD, Devon, England
[4] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands
[5] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, NL-6500 HB Nijmegen, Netherlands
[6] Univ Bonn, Dept Immunol & Metab, Life & Med Sci Inst, D-53115 Bonn, Germany
[7] Europe Middle East & Africa Innovat Ctr, Johnson Johnson Innovat, London W1G 0BG, England
[8] Roche Int Ltd, Dept Med, Montevideo 11300, Uruguay
[9] Univ Dundee, Div Mol Microbiol, Sch Life Sci, Dundee DD1 5EH, Scotland
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2021年 / 118卷 / 15期
基金：
英国医学研究理事会; 英国工程与自然科学研究理事会; 欧洲研究理事会;
关键词：
macrophages; fungal hyphae; mechanical force; podosomes; cytoskeleton; ACTIVATED PROTEIN-KINASE; CANDIDA-ALBICANS; MYOSIN-II; MECHANICAL FORCES; RECEPTOR; PHAGOCYTOSIS; RECOGNITION; DECTIN-1; PHOSPHORYLATION; STRESS;
D O I：
10.1073/pnas.2020484118
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Innate immunity provides essential protection against life-threatening fungal infections. However, the outcomes of individual skirmishes between immune cells and fungal pathogens are not a foregone conclusion because some pathogens have evolved mechanisms to evade phagocytic recognition, engulfment, and killing. For example, Candida albicans can escape phagocytosis by activating cellular morphogenesis to form lengthy hyphae that are challenging to engulf. Through live imaging of C. albicans-macrophage interactions, we discovered that macrophages can counteract this by folding fungal hyphae. The folding of fungal hyphae is promoted by Dectin-1, beta 2-integrin, VASP, actin-myosin polymerization, and cell motility. Folding facilitates the complete engulfment of long hyphae in some cases and it inhibits hyphal growth, presumably tipping the balance toward successful fungal clearance.
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页数：8
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共 78 条
  • [1] Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    Adachi, O
    Kawai, T
    Takeda, K
    Matsumoto, M
    Tsutsui, H
    Sakagami, M
    Nakanishi, K
    Akira, S
    [J]. IMMUNITY, 1998, 9 (01) : 143 - 150
  • [2] Toll-like receptor signalling
    Akira, S
    Takeda, K
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) : 499 - 511
  • [3] Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages
    Allen, LAH
    Aderem, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) : 627 - 637
  • [4] Candida albicans Hypha Formation and Mannan Masking of β-Glucan Inhibit Macrophage Phagosome Maturation
    Bain, Judith M.
    Louw, Johanna
    Lewis, Leanne E.
    Okai, Blessing
    Walls, Catriona A.
    Ballou, Elizabeth R.
    Walker, Louise A.
    Reid, Delyth
    Munro, Carol A.
    Brown, Alistair J. P.
    Brown, Gordon D.
    Gow, Neil A. R.
    Erwig, Lars P.
    [J]. MBIO, 2014, 5 (06):
  • [5] Lactate signalling regulates fungal β-glucan masking and immune evasion
    Ballou, Elizabeth R.
    Avelar, Gabriela M.
    Childers, Delma S.
    Mackie, Joanna
    Bain, Judith M.
    Wagener, Jeanette
    Kastora, Stavroula L.
    Panea, Mirela D.
    Hardison, Sarah E.
    Walker, Louise A.
    Erwig, Lars P.
    Munro, Carol A.
    Gow, Neil A. R.
    Brown, Gordon D.
    MacCallum, DonnaM.
    Brown, Alistair J. P.
    [J]. NATURE MICROBIOLOGY, 2017, 2 (02):
  • [6] Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans
    Behnsen, Judith
    Narang, Priyanka
    Hasenberg, Mike
    Gunzer, Frank
    Bilitewski, Ursula
    Klippel, Nina
    Rohde, Manfred
    Brock, Matthias
    Brakhage, Axel A.
    Gunzer, Matthias
    [J]. PLOS PATHOGENS, 2007, 3 (02) : 138 - 151
  • [7] Podosome-type adhesions and focal adhesions, so alike yet so different
    Block, Marc R.
    Badowski, Cedric
    Millon-Fremillon, Angelique
    Bouvard, Daniel
    Bouin, Anne-Pascale
    Faurobert, Eva
    Gerber-Scokaert, Delphine
    Planus, Emmanuelle
    Albiges-Rizo, Corinne
    [J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2008, 87 (8-9) : 491 - 506
  • [8] AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein
    Blume, Constanze
    Benz, Peter M.
    Walter, Ulrich
    Ha, Joohun
    Kemp, Bruce E.
    Renne, Thomas
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (07) : 4601 - 4612
  • [9] Cdc42 GTPase dynamics control directional growth responses
    Brand, Alexandra C.
    Morrison, Emma
    Milne, Stephen
    Gonia, Sara
    Gale, Cheryl A.
    Gow, Neil A. R.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (02) : 811 - 816
  • [10] Control of filament formation in Candida albicans by the transcriptional repressor TUP1
    Braun, BR
    Johnson, AD
    [J]. SCIENCE, 1997, 277 (5322) : 105 - 109
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