Relative Biological Effect/Linear Energy Transfer in Proton Beam Therapy: A Primer

被引:8
作者
Gulliford, S. L. [1 ]
Prise, K. M. [2 ]
机构
[1] Univ Coll London Hosp, Dept Radiotherapy Phys, London, England
[2] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, Antrim, North Ireland
基金
英国工程与自然科学研究理事会;
关键词
MODEL; RADIOBIOLOGY;
D O I
10.1016/j.clon.2019.06.009
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:809 / 812
页数:4
相关论文
共 15 条
[1]   Proton Beam Therapy - the Challenges of Delivering High-quality Evidence of Clinical Benefit [J].
Amos, R. ;
Bulbeck, H. ;
Burnet, N. G. ;
Crellin, A. ;
Eaton, D. ;
Evans, P. ;
Hall, E. ;
Hawkins, M. A. ;
Kirkby, K. J. ;
Mackay, R. ;
Sebag-Montefiore, D. ;
Sharma, R. .
CLINICAL ONCOLOGY, 2018, 30 (05) :280-284
[2]   The incorporation of the concept of minimum RBE (RBEmin) into the linear-quadratic model and the potential for improved radiobiological analysis of high-LET treatments [J].
Carabe-Fernandez, Alejandro ;
Dale, Roger G. ;
Jones, Bleddyn .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2007, 83 (01) :27-39
[3]   Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury [J].
Giantsoudi, Drosoula ;
Sethi, Roshan V. ;
Yeap, Beow Y. ;
Eaton, Bree R. ;
Ebb, David H. ;
Caruso, Paul A. ;
Rapalino, Otto ;
Chen, Yen-Lin E. ;
Adams, Judith A. ;
Yock, Torunn I. ;
Tarbell, Nancy J. ;
Paganetti, Harald ;
MacDonald, Shannon M. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2016, 95 (01) :287-296
[4]   INITIAL EVENTS IN THE CELLULAR EFFECTS OF IONIZING-RADIATIONS - CLUSTERED DAMAGE IN DNA [J].
GOODHEAD, DT .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1994, 65 (01) :7-17
[5]   The Radiobiology of Proton Therapy: Challenges and Opportunities Around Relative Biological Effectiveness [J].
Jones, B. ;
McMahon, S. J. ;
Prise, K. M. .
CLINICAL ONCOLOGY, 2018, 30 (05) :285-292
[6]   "Radiobiology of Proton Therapy": Results of an international expert workshop [J].
Luehr, Armin ;
von Neubeck, Claere ;
Pawelke, Joerg ;
Seidlitz, Annekatrin ;
Peitzsch, Claudia ;
Bentzen, Soren M. ;
Bortfeld, Thomas ;
Debus, Juergen ;
Deutsch, Eric ;
Langendijk, Johannes A. ;
Loeffler, Jay S. ;
Mohan, Radhe ;
Scholz, Michael ;
Sorensen, Brita S. ;
Weber, Damien C. ;
Baumann, Michael ;
Krause, Mechthild .
RADIOTHERAPY AND ONCOLOGY, 2018, 128 (01) :56-67
[7]   Mechanistic Modelling of Radiation Responses [J].
McMahon, Stephen J. ;
Prise, Kevin M. .
CANCERS, 2019, 11 (02)
[8]   A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data [J].
McNamara, Aimee L. ;
Schuemann, Jan ;
Paganetti, Harald .
PHYSICS IN MEDICINE AND BIOLOGY, 2015, 60 (21) :8399-8416
[9]   Clinical Indications for Carbon Ion Radiotherapy [J].
Mohamad, O. ;
Yamada, S. ;
Durante, M. .
CLINICAL ONCOLOGY, 2018, 30 (05) :317-329
[10]   Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy [J].
Paganetti, Harald ;
Blakely, Eleanor ;
Carabe-Fernandez, Alejandro ;
Carlson, David J. ;
Das, Indra J. ;
Dong, Lei ;
Grosshans, David ;
Held, Kathryn D. ;
Mohan, Radhe ;
Moiseenko, Vitali ;
Niemierko, Andrzej ;
Stewart, Robert D. ;
Willers, Henning .
MEDICAL PHYSICS, 2019, 46 (03) :E53-E78