Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols

被引：15

作者：

Pan, Feng-Feng ^{[1
,2
]}

Guo, Peng ^{[1
]}

Huang, Xiaochuang ^{[3
]}

Shu, Xing-Zhong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem SKLAOC, 222 South Tianshui Rd, Lanzhou 730000, Peoples R China

[2] Tianshui Normal Univ, Coll Chem Engn & Technol, 60 South Xihe Rd, Tianshui 741001, Peoples R China

[3] Jiangsu Tasly Diyi Pharmaceut Co Ltd, 168 West Chaoyang Rd, Huaian 223003, Jiangsu, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2021年 / 53卷 / 17期

基金：

中国国家自然科学基金;

关键词：

homocoupling; nickel; dibenzyls; alcohols; synthetic methodology;

D O I：

10.1055/a-1467-2432

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dibenzyls are essential building blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary alcohols are tolerated.

引用

页码：3094 / 3100

页数：7

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