Dietary glycemic index modulates the behavioral and biochemical abnormalities associated with autism spectrum disorder

Autisryt spectruni disorder (ASD) is a con-ilalex neiJrodeveloprnental disorder of iJnknown etiology, but very likely resulting from both genetic and environmental factors. There is good evidence for inimuile system dysregulation in individuals with ASD. However, the contribution of insults such as dietary factors that can also activate the immune system have not been explored in the context of ASD. In this paper, we show that the dietery glycenlic index has a sigriificant impact on the ASD phenotype. By using BTBR mice, an inbred strain that displays behavioral traits that reflect the diagnostic synIptorns of human ASD, we found that the diet modulates plasma metabolites, neuroinflammation and brain markers of netirogenesis in a manner that is highly reflective of ASD in humans. Overall, the rrianuscript supports the idea that ASD results from gene environment interactions and that in the Preisencie of a genetic predisposition ASD, diet can make a large difference in the expression of the condition