Metal-Free Three-Component Regioselective Aminofluorination of Styrene Derivatives

被引：30

作者：

Zhang, Qiao ^{[1
]}

Zheng, Guangfan ^{[1
]}

Zhang, Qian ^{[1
]}

Li, Yan ^{[1
]}

Zheng, Qan ^{[1
]}

机构：

[1] Northeast Normal Univ, Dept Chem, Key Lab Funct Organ Mol Design & Synth Jilin Prov, 5268 Renmin Rd, Changchun 130024, Jilin, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 15期

基金：

中国国家自然科学基金;

关键词：

UNACTIVATED ALKENES; AQUEOUS-SOLUTION; INTRAMOLECULAR AMINOFLUORINATION; INTERMOLECULAR AMINOFLUORINATION; OLEFIN AMINOFLUORINATION; MEDICINAL CHEMISTRY; FLUORINATION; CARBOFLUORINATION; AMINATION; ALKYNES;

D O I：

10.1021/acs.joc.7b01089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first metal-free, three-component radical aminofluorination of styrene derivatives has been developed, which employs Selectfluor as a fluorine source and azole derivatives as a nitrogen source. This transformation proceeds with high regioselectivity, providing various 1,2-aminofluorination compounds under mild conditions. Mechanistic studies suggest that the aminofluorination process might involve radical fluorination followed by nucleophilic amination.

引用

页码：8258 / 8266

页数：9

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