Neuroprotective effect of geranylgeranylacetone, a noninvasive heat shock protein inducer, on cerebral infarction in rats

被引：14

作者：

Nagai, Y ^{[1
]}

Fujiki, M ^{[1
]}

Inoue, R ^{[1
]}

Uchida, S ^{[1
]}

Abe, T ^{[1
]}

Kobayashi, H ^{[1
]}

Cetinalp, NE ^{[1
]}

机构：

[1] Oita Univ, Sch Med, Dept Neurosurg, Oita 8795593, Japan

来源：

NEUROSCIENCE LETTERS | 2005年 / 374卷 / 03期

关键词：

geranylgeranylacetone; cerebral ischemia; middle cerebral artery occlusion; neuronal death; preconditioning; neuroprotection; rat;

D O I：

10.1016/j.neulet.2004.10.070

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study evaluated the neuroprotective effect of geranylgeranylacetone (GGA), which is known as an antiulcer agent and more recently as a heat shock protein (HSP) inducer, against cerebral infarction induced by permanent left middle cerebral artery (MCA) occlusion. GGA was given orally in various regimens prior to MCA occlusion in rats. Pretreatment with a single oral GGA dose (800 mg/kg) 48 It before ischemia significantly attenuated cerebral infarction volume (81.7 +/- 18.4 mm(3) versus 369.1 +/- 70.2 mm(3); P<.01). A significant increase in HSP70 immunoreactivity was found in the neocortex in GGA-treated animals with or without ischemia. Pretreatment with a single oral dose of GGA provides an important tool for exploring the mechanisms of neuroprotection against cerebral ischemic neuronal damage. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：183 / 188

页数：6

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