The future of early cancer detection

被引：243

作者：

Fitzgerald, Rebecca C. ^{[1
]}

Antoniou, Antonis C. ^{[2
]}

Fruk, Ljiljana ^{[3
]}

Rosenfeld, Nitzan ^{[4
]}

机构：

[1] Univ Cambridge, Canc Res UK Cambridge Ctr, Early Detect Programme, Cambridge, England

[2] Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England

[3] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England

[4] Univ Cambridge, Canc Res UK Cambridge Inst, Li Ka Shing Ctr, Cambridge, England

来源：

NATURE MEDICINE | 2022年 / 28卷 / 04期

关键词：

OFFSET RAMAN-SPECTROSCOPY; BREAST-CANCER; PROSTATE-CANCER; ARTIFICIAL-INTELLIGENCE; OXIDE NANOPARTICLES; GOLD NANOPARTICLES; CONTRAST AGENTS; RISK; MODEL; CARE;

D O I：

10.1038/s41591-022-01746-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A proactive approach to detecting cancer at an early stage can make treatments more effective, with fewer side effects and improved long-term survival. However, as detection methods become increasingly sensitive, it can be difficult to distinguish inconsequential changes from lesions that will lead to life-threatening cancer. Progress relies on a detailed understanding of individualized risk, clear delineation of cancer development stages, a range of testing methods with optimal performance characteristics, and robust evaluation of the implications for individuals and society. In the future, advances in sensors, contrast agents, molecular methods, and artificial intelligence will help detect cancer-specific signals in real time. To reduce the burden of cancer on society, risk-based detection and prevention needs to be cost effective and widely accessible. Technological advances are producing exquisitely sensitive cancer detection tests. This Review discusses who should be tested, and how-and looks to the future of personalized, risk-based cancer screening.

引用

页码：666 / 677

页数：12

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