Chemical constituents of Blumea balsamifera

被引：10

作者：

Hanh, Tran Thi Hong ^{[1
]}

Hang, Le Thi Thuy ^{[1
,2
]}

Giang, Vu Huong ^{[1
]}

Trung, Nguyen Quang ^{[3
]}

Thanh, Nguyen Van ^{[1
,2
]}

Quang, Tran Hong ^{[1
]}

Cuong, Nguyen Xuan ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Grad Univ Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam

[3] VAST, Ctr Res & Technol Transfer, 18 Hoang Quoc Viet, Hanoi, Vietnam

来源：

PHYTOCHEMISTRY LETTERS | 2021年 / 43卷

关键词：

Blumea balsamifera; Asteraceae; Secondary metabolite; Cytotoxicity; GLYCOSIDES; ROOTS;

D O I：

10.1016/j.phytol.2021.03.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigations of Blumea balsamifera branches and leaves led to the isolation of ten secondary metabolites, including three new compounds, namely, balsamiferine K (1) and balsamiferosides A (2) and B (3). Structural elucidation was confirmed by detailed analysis of the 1D and 2D NMR spectra as well as HR-ESI-QTOF mass spectra. Among the isolated compounds, blumeaene J (4) exhibited moderate cytotoxicity against LNCaP (IC50 = 44.53 +/- 4.95 mu M) and SK-Mel2 (IC50 = 46.49 +/- 3.84 mu M) cell lines and weak effects on HepG2 (IC50 = 61.54 +/- 2.98 mu M), KB (IC50 = 65.40 +/- 4.97 mu M), and MCF-7 (IC50 = 70.06 +/- 5.65 mu M) cell lines, whereas (-)-angelicoidenol 2-O-/9-D-glucopyranoside (6) revealed weak activity on all five tested cancer cell lines, with IC50 values ranging from 61.60 +/- 5.64-98.73 +/- 2.24 mu M.

引用

页码：35 / 39

页数：5

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