Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development

被引：30
作者：
Yang, Ailin [1 ]
Wu, Yanjun [1 ]
Yu, Ganggang [1 ]
Wang, Haoyan [1 ]
机构：
[1] Capital Med Univ, Beijing Friendship Hosp, Dept Resp Med, 95 Yong An Rd, Beijing 100050, Peoples R China
来源：
RESPIRATORY RESEARCH | 2021年 / 22卷 / 01期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
Inflammation resolution; Lung diseases; Lung inflammation; Pro-resolving lipid mediators; Mechanism; NEUTROPHIL EXTRACELLULAR TRAPS; ASPIRIN-TRIGGERED LIPOXINS; PPAR-GAMMA; ANNEXIN A1; EPITHELIAL-CELLS; INFLUENZA-VIRUS; MARESIN; BRONCHOPULMONARY DYSPLASIA; ALTERNATIVE ACTIVATION; TUBERCULOSIS INFECTION;
D O I：
10.1186/s12931-021-01792-y
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Inflammation is an essential mechanism of various diseases. The development and resolution of inflammation are complex immune-modulation processes which induce the involvement of various types of immune cells. Specialized pro-resolving lipid mediators (SPMs) have been demonstrated to be signaling molecules in inflammation. SPMs are involved in the pathophysiology of different diseases, especially respiratory diseases, including asthma, pneumonia, and chronic obstructive pulmonary disease. All of these diseases are related to the inflammatory response and its persistence. Therefore, a deeper understanding of the mechanisms and development of inflammation in respiratory disease, and the roles of the SPM family in the resolution process, might be useful in the quest for novel therapies and preventive measures for pulmonary diseases.
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收藏
页数：17
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