Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

被引:15
作者
Li, Ang [1 ,2 ]
Ling, Yun [1 ,2 ]
Song, Zhigang [1 ,2 ]
Cheng, Xiaobo [1 ,2 ]
Ding, Longfei [1 ,2 ]
Jiang, Rendi [3 ]
Fu, Weihui [1 ,2 ]
Liu, Yan [1 ,2 ]
Hu, Huiliang [1 ,2 ]
Yuan, Songhua [1 ,2 ]
Chen, Jian [1 ,2 ]
Zhu, Cuisong [1 ,2 ]
Fan, Jun [1 ,2 ]
Wang, Jing [1 ,2 ]
Jin, Yanling [1 ,2 ]
Zhang, Miaomiao [1 ,2 ]
Zhu, Lingyan [1 ,2 ]
Sun, Peng [1 ,2 ]
Zhang, Linxia [1 ,2 ]
Qin, Ran [1 ,2 ]
Zhang, Wei [1 ,2 ]
Qin, Chenli [1 ,2 ]
Shen, Yinzhong [1 ,2 ]
Zhang, Lin [1 ,2 ]
Shi, Zhengli [3 ]
Zhao, Chen [1 ,2 ]
Zhu, Tongyu [1 ,2 ]
Lu, Hongzhou [1 ,2 ]
Zhang, Xiaoyan [1 ,2 ]
Xu, Jianqing [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
[3] Chinese Acad Sci, Wuhan Inst Virol, Key Lab Special Pathogens, Wuhan, Peoples R China
基金
美国国家科学基金会;
关键词
IL-37; SARS-CoV-2; COVID-19; inflammation; clinical outcomes; IL-37; CELLS; FORMS;
D O I
10.1093/infdis/jiaa713
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for the development of an effective intervention approach. Methods. We examined early responses of interleukin 37 (IL-37), a powerful anti-inflammatory cytokine, in 254 SARS-CoV-2-infected patients before any clinical intervention and determined its correlation with clinical prognosis. Results. Our results demonstrated that SARS-CoV-2 infection causes elevation of plasma IL-37. Higher early IL-37 responses were correlated with earlier viral RNA negative conversion, chest computed tomographic improvement, and cough relief, consequently resulted in earlier hospital discharge. Further assays showed that higher IL-37 was associated with lower interleukin 6 and interleukin 8 (IL-8) and higher interferon a responses and facilitated biochemical homeostasis. Low IL-37 responses predicted severe clinical prognosis in combination with IL-8 and C-reactive protein. In addition, we observed that IL-37 administration was able to attenuate lung inflammation and alleviate respiratory tissue damage in human angiotensin-converting enzyme 2-transgenic mice infected with SARS-CoV-2. Conclusions. Overall, we found that IL-37 plays a protective role by antagonizing inflammatory responses while retaining type I interferon, thereby maintaining the functionalities of vital organs. IL-37, IL-8, and C-reactive protein might be formulated as a precise prediction model for screening severe clinical cases and have good value in clinical practice.
引用
收藏
页码:568 / 580
页数:13
相关论文
共 32 条
  • [1] Suppression of inflammation and acquired immunity by IL-37
    Cavalli, Giulio
    Dinarello, Charles A.
    [J]. IMMUNOLOGICAL REVIEWS, 2018, 281 (01) : 179 - 190
  • [2] Anti-Inflammatory Effect of IL-37-Producing T-Cell Population in DSS-Induced Chronic Inflammatory Bowel Disease in Mice
    Chen, Zhangbo
    Wang, Shijun
    Li, Lingyun
    Huang, Zhong
    Ma, Ke
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
  • [3] The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system
    Coperchini, Francesca
    Chiovato, Luca
    Croce, Laura
    Magri, Flavia
    Rotondi, Mario
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2020, 53 : 25 - 32
  • [4] Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease
    Fonseca-Camarillo, Gabriela
    Furuzawa-Carballeda, Janette
    Yamamoto-Furusho, Jesus K.
    [J]. CYTOKINE, 2015, 75 (02) : 389 - 402
  • [5] Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity
    Grimsby, S
    Jaensson, H
    Dubrovska, A
    Lomnytska, M
    Hellman, U
    Souchelnytskyi, S
    [J]. FEBS LETTERS, 2004, 577 (1-2): : 93 - 100
  • [6] Clinical Characteristics of Coronavirus Disease 2019 in China
    Guan, W.
    Ni, Z.
    Hu, Yu
    Liang, W.
    Ou, C.
    He, J.
    Liu, L.
    Shan, H.
    Lei, C.
    Hui, D. S. C.
    Du, B.
    Li, L.
    Zeng, G.
    Yuen, K. -Y.
    Chen, R.
    Tang, C.
    Wang, T.
    Chen, P.
    Xiang, J.
    Li, S.
    Wang, Jin-lin
    Liang, Z.
    Peng, Y.
    Wei, L.
    Liu, Y.
    Hu, Ya-hua
    Peng, P.
    Wang, Jian-ming
    Liu, J.
    Chen, Z.
    Li, G.
    Zheng, Z.
    Qiu, S.
    Luo, J.
    Ye, C.
    Zhu, S.
    Zhong, N.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (18) : 1708 - 1720
  • [7] Human dendritic cells express the IL-18R and are chemoattracted to IL-18
    Gutzmer, R
    Langer, K
    Mommert, S
    Wittmann, M
    Kapp, A
    Werfel, T
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 171 (12) : 6363 - 6371
  • [8] Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
    Hadjadj, Jerome
    Yatim, Nader
    Barnabei, Laura
    Corneau, Aurelien
    Boussier, Jeremy
    Smith, Nikaia
    Pere, Helene
    Charbit, Bruno
    Bondet, Vincent
    Chenevier-Gobeaux, Camille
    Breillat, Paul
    Carlier, Nicolas
    Gauzit, Remy
    Morbieu, Caroline
    Pene, Frederic
    Marin, Nathalie
    Roche, Nicolas
    Szwebel, Tali-Anne
    Merkling, Sarah H.
    Treluyer, Jean-Marc
    Veyer, David
    Mouthon, Luc
    Blanc, Catherine
    Tharaux, Pierre-Louis
    Rozenberg, Flore
    Fischer, Alain
    Duffy, Darragh
    Rieux-Laucat, Frederic
    Kerneis, Solen
    Terrier, Benjamin
    [J]. SCIENCE, 2020, 369 (6504) : 718 - +
  • [9] Interleukin-37 alleviates airway inflammation and remodeling in asthma via inhibiting the activation of NF-κB and STAT3 signalings
    Huang, Nina
    Liu, Kebei
    Liu, Jianping
    Gao, Xiaopeng
    Zeng, Zhu
    Zhang, Yudan
    Chen, Jing
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 55 : 198 - 204
  • [10] Insight into interleukin-37: The potential therapeutic target in allergic diseases
    Huang, Zhaohao
    Xie, Lihui
    Li, He
    Liu, Xiuxing
    Bellanti, Joseph A.
    Zheng, Song Guo
    Su, Wenru
    [J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2019, 49 : 32 - 41