Repurposing Drugs: Lessons from Rheumatology in the COVID-19 Pandemic

被引：1

作者：

Manoj, Manesh ^{[1
]}

Bafna, Prashant ^{[1
]}

Sahoo, Rasmi Ranjan ^{[1
]}

Hazarika, Kasturi ^{[1
]}

Wakhlu, Anupam ^{[1
]}

机构：

[1] King Georges Med Univ, Dept Clin Immunol & Rheumatol, Lucknow 226003, Uttar Pradesh, India

来源：

INDIAN JOURNAL OF RHEUMATOLOGY | 2021年 / 16卷 / 02期

关键词：

Artificial intelligence; bacillus Calmette-Guerin; cytokine storm; drug repositioning; drug repurposing; vaccinology; INFLAMMATION; MECHANISMS; INJURY;

D O I：

10.4103/injr.injr_323_20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Humanity currently faces one of its biggest challenges, created by a tiny quasi-life form, the severe acute respiratory syndrome coronavirus 2. The rapidity of spread and the enormous burden placed on public health infrastructure by the coronavirus disease 2019 (COVID-19) pandemic has forced researchers to look for quick answers for therapy. Drug repurposing is probably the quickest way to develop an effective therapy in a very short time. With additional input from artificial intelligence (AI), drug repurposing may emerge as one of the major techniques by which humanity can overcome this as well as future challenges. The field of rheumatology has been one of the biggest benefactors of drug repurposing. This article reviews the various ways drugs used in rheumatological disorders are being repurposed for possible COVID-19 treatment. An overview of other nonantiviral drugs being repurposed is also undertaken, and the role of AI in drug repurposing is touched upon.

引用

页码：179 / 186

页数：8

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