HEAD-DROP: A FREQUENT FEATURE OF LATE-ONSET MYASTHENIA GRAVIS

被引：17
|
作者：
Sih, Marvin [1 ]
Soliven, Betty [1 ]
Mathenia, Nicholas [1 ]
Jacobsen, John [1 ]
Rezania, Kourosh [1 ]
机构：
[1] Univ Chicago, Med Ctr, Dept Neurol, 5841 S Maryland Ave,MC 2030, Chicago, IL 60637 USA
来源：
MUSCLE & NERVE | 2017年 / 56卷 / 03期
关键词：
acetylcholine receptor antibody; dropped head; head-drop; late-onset; MuSK; myasthenia gravis; respiratory weakness; PROTEIN; 4; AUTOANTIBODIES; MUSK; SIGN; MYOPATHY; DISEASE;
D O I：
10.1002/mus.25526
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: Head-drop is often encountered in myasthenia gravis (MG) patients, but its frequency and clinical course have not been studied systematically. Methods: In a retrospective study of a cohort of MG patients seen over a period of 11 years in a tertiary medical center, we assessed the clinical characteristics of patients who had head-drop. Results: Of 146 generalized MG patients, 15 had head-drop during the course of their disease. Head-drop patients had older age of onset than those who did not have head-drop (mean age of onset 59.1 vs. 42.3 years) and were predominantly men. Head-drop was present in 23% of patients > 60 versus 6% of those < 60 years, and it improved in 9 of 11 patients with treatment directed to generalized MG. Conclusions: Head-drop is a common, treatment-responsive manifestation of late-onset MG.
引用
收藏
页码：441 / 444
页数：4
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