Gold(I)-Catalyzed Enantioselective Polycyclization Reactions

被引：164

作者：

Sethofer, Steven G. ^{[1
]}

Mayer, Timo ^{[1
]}

Toste, F. Dean ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 24期

关键词：

POLYENE CYCLIZATION; REARRANGEMENTS; CYCLOISOMERIZATIONS; TRITERPENE; GOLD(I);

D O I：

10.1021/ja103544p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of enantioselective polycyclization reactions, catalyzed by a cationic bisphosphine gold complexes, are described. The polycyclization reactions, which employ an alkyne as an initiating group, begin with a gold-promoted 6-exo-dig cyclization and can be terminated with a variety of nucleophiles including carboxylic acids, phenols, sulfonamides, and electron-rich aryl groups. This method allows for the preparation of up to four bonds in a single operation with excellent diastereo- and enantioselectivity.

引用

页码：8276 / +

页数：3

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