A highly enantioselective Hg(II)-catalyzed Sakurai-Hosomi reaction of isatins with allyltrimethylsilanes

被引：35

作者：

Cao, Zhong-Yan ^{[1
]}

Jiang, Jia-Sheng ^{[2
]}

Zhou, Jian ^{[1
,3
]}

机构：

[1] E China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China

[2] Mengcheng 1 Middle Sch, Bozhou 233500, Anhui, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 24期

关键词：

CATALYZED ASYMMETRIC ALLYLATION; VINYLOGOUS ALDOL REACTION; SPIROCYCLIC OXINDOLES; CARBONYL-COMPOUNDS; ACID; IMINES; HG(CLO4)(2)CENTER-DOT-3H(2)O; 3-HYDROXYOXINDOLES; CYCLOPROPANATION; DIAZOOXINDOLES;

D O I：

10.1039/c5ob02582f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chiral complex derived from (S)-difluorophos and Hg(OTf)(2) is identified as a powerful catalyst for the Sakurai-Hosomi reaction of isatins with allyltrimethylsilane, allowing the facile synthesis of valuable building blocks 3-allyl-3-hydroxyoxindoles in up to 97% ee, with only 0.5-1.0 mol% of catalyst loading.

引用

页码：5500 / 5504

页数：5

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