Gold Nanoparticle-Fluorophore Complexes: Sensitive and Discerning "Noses" for Biosystems Sensing

被引：317

作者：

Bunz, Uwe H. F. ^{[1
]}

Rotello, Vincent M. ^{[2
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

[2] Univ Massachusetts, Dept Chem, Amherst, MA 01003 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 19期

基金：

美国国家科学基金会;

关键词：

biosensors; displacement assays; fluorescent probes; nanoparticles; COLORIMETRIC SENSOR ARRAY; CARBOXYLATE-SUBSTITUTED PPE; CONJUGATED POLYMERS; BACTERIA; RECOGNITION; IDENTIFICATION; PROTEINS; BINDING; DIFFERENTIATION; RECEPTORS;

D O I：

10.1002/anie.200906928

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles (NPs) efficiently quench adsorbed fluorophores. Upon disruption of such complexes by an analyte, fluorescence turnon is observed. By judicious choice of the functionalized NP and the fluorophore, these complexes display different responses to analytes, thus leading to versatile yet simple array-based sensor platforms. Using this strategy, we can identify proteins in buffer and serum, distinguish between both different species and different strains of bacteria, and differentiate between healthy, cancerous, and metastatic human and murine cells. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3268 / 3279

页数：12

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