Analysis of glutathionyl hemoglobin levels in diabetic patients by electrospray ionization liquid chromatography-mass spectrometry: effect of vitamin E administration

被引：20

作者：

Naito, C ^{[1
]}

Niwa, T ^{[1
]}

机构：

[1] Nagoya Univ, Daiko Med Ctr, Higashi Ku, Nagoya, Aichi 4610047, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B | 2000年 / 746卷 / 01期

关键词：

glutathionyl hemoglobulin; vitamins;

D O I：

10.1016/S0378-4347(00)00121-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

By using electrospray ionization liquid chromatography-mass spectrometry, we demonstrated that glutathionyl hemoglobin (Hb)beta-chain levels are markedly increased in the erythrocytes of diabetic patients as compared with healthy subjects. The administration of vitamin E to the diabetic patients for 8 weeks significantly decreased the levels of glutathionyl Hb beta, whereas it did not affect the levels of HbA1c, glycated Hb beta or glycated Hb alpha. Glutathionyl Hb levels can be used as a new clinical marker of oxidative stress. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：91 / 94

页数：4

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