Glutathione S-transferase M1 and T1 polymorphisms and the risk of recurrent pregnancy loss

被引：53
作者：
Sata, F
Yamada, H
Kondo, T
Gong, Y
Tozaki, S
Kobashi, G
Kato, EH
Fujimoto, S
Kishi, R
机构：
[1] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Kita Ku, Sapporo, Hokkaido 0608638, Japan
[2] Hokkaido Univ, Sch Med, Dept Obstet & Gynecol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
来源：
MOLECULAR HUMAN REPRODUCTION | 2003年 / 9卷 / 03期
基金：
日本学术振兴会;
关键词：
genetic polymorphism; glutathione S-transferase M1; glutathione S-transferase T1; molecular epidemiology; recurrent pregnancy loss;
D O I：
10.1093/molehr/gag021
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aetiology of recurrent pregnancy loss (RPL) remains unclear, but it may be related to a possible genetic predisposition together with involvement of environmental factors. We examined the relation between RPL and polymorphisms in two genes, glutathione S-transferases (GST) M1 and T1, which are involved in the metabolism of a wide range of environmental toxins and carcinogens. A case-control study of 115 cases with RPL and 160 controls was conducted. All cases and controls were women resident in Sapporo, Japan and the surrounding area. They were genotyped for polymorphisms of GSTM1 and GSTT1 using PCR-based methods. We found that 65.2% of the cases with RPL and.45.6% of the controls had the GSTM1 null genotype [odds ratio (OR) = 2.23 95% confidence interval (CI) = 1.36-3.66]. On the other hand, 47.0% of the cases and 49.4% of the controls had the GSTT1 null genotype (OR = 0.95; 95% CI = 0.58-1.55). The results suggest that women with GSTM1 null polymorphism may therefore have an increased risk of RPL.
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收藏
页码：165 / 169
页数：5
相关论文
共 32 条
[1]  
[Anonymous], 2007, DESIGNING CLIN RES P
[2]   Low-penetrance genes are associated with increased susceptibility to endometriosis [J].
Arvanitis, DA ;
Goumenou, AG ;
Matalliotakis, IM ;
Koumantakis, EE ;
Spandidos, DA .
FERTILITY AND STERILITY, 2001, 76 (06) :1202-1206
[3]   Proportion of the GSTM1 0/0 genotype in some Slavic populations and its correlation with cystic fibrosis and some multifactorial diseases [J].
Baranov, VS ;
Ivaschenko, T ;
Bakay, B ;
Aseev, M ;
Belotserkovskaya, R ;
Baranova, H ;
Malet, P ;
Perriot, J ;
Mouraire, P ;
Baskakov, VN ;
Savitskyi, GA ;
Gorbushin, S ;
Deyneka, SI ;
Michnin, E ;
Barchuck, A ;
Vakharlovsky, V ;
Pavlov, G ;
Shilko, VI ;
Guembitzkaya, T ;
Kovaleva, L .
HUMAN GENETICS, 1996, 97 (04) :516-520
[4]   Glutathione S-transferase M1 gene polymorphism and susceptibility to endometriosis in a French population [J].
Baranova, H ;
Bothorishvilli, R ;
Canis, M ;
Albuisson, E ;
Perriot, S ;
Glowaczower, E ;
Bruhat, MA ;
Baranov, V ;
Malet, P .
MOLECULAR HUMAN REPRODUCTION, 1997, 3 (09) :775-780
[5]   Possible involvement of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 genes in the development of endometriosis [J].
Baranova, H ;
Canis, M ;
Ivaschenko, T ;
Albuisson, E ;
Bothorishvilli, R ;
Baranov, V ;
Malet, P ;
Bruhat, MA .
MOLECULAR HUMAN REPRODUCTION, 1999, 5 (07) :636-641
[6]   Increased risk for myelodysplastic syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect [J].
Chen, HW ;
Sandler, DP ;
Taylor, JA ;
Shore, DL ;
Liu, E ;
Bloomfield, CD ;
Bell, DA .
LANCET, 1996, 347 (8997) :295-297
[7]   The epidemiology of recurrent pregnancy loss [J].
Cramer, DW ;
Wise, LA .
SEMINARS IN REPRODUCTIVE MEDICINE, 2000, 18 (04) :331-339
[8]  
Dwivedi RS, 1998, REPROD DEV TOXICOLOG, P11
[9]  
Fenster L, 1991, Epidemiology, V2, P168, DOI 10.1097/00001648-199105000-00002
[10]   Environmental toxins associated with recurrent pregnancy loss [J].
Gardella, JR ;
Hill, JA .
SEMINARS IN REPRODUCTIVE MEDICINE, 2000, 18 (04) :407-424
1234