Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory

被引：56
作者：
Aqrabawi, Afif J. [1 ]
Kim, Jun Chul [1 ,2 ]
机构：
[1] Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M5S 3G5, Canada
[2] Univ Toronto, Dept Psychol, Toronto, ON M5S 3G5, Canada
来源：
NATURE COMMUNICATIONS | 2018年 / 9卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; ORGANIZATION; PLACE; DEFICITS; PLAQUES; TANGLES; CORTEX; REACTIVATION; NEURONS;
D O I：
10.1038/s41467-018-05131-6
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory.
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页数：10
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