New strategies for the prevention of stroke

被引：11

作者：

Liu, Ai-Jun ^{[1
]}

Guo, Jin-Min ^{[1
]}

Xia, Weiliang ^{[2
]}

Su, Ding-Feng ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacol, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2010年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

arterial baroreflex; folic acid; hypertension; pro-inflammatory factor; risk factor; stroke prevention; C-REACTIVE PROTEIN; ARTERIAL BAROREFLEX FUNCTION; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; ISCHEMIC-STROKE; FOLIC-ACID; VITAMIN-D; POSTMENOPAUSAL WOMEN; RISK-FACTORS;

D O I：

10.1111/j.1440-1681.2009.05230.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Stroke is a major cause of disability and death worldwide. It is preferable to prevent stroke rather than to treat it and, for the prevention of stroke, all risk factors relating to stroke need to be understood. The present paper reviews potential new strategies for the prevention of stroke based on findings of new risk factors, as well as classical risk factors. 2. Recently, new risk factors related to stroke were reported, including dysfunction of the arterial baroreflex, pro-inflammatory cytokines, vitamins and hormone deficiency. Correspondingly, therapies targeting these risk factors where shown to significantly reduce the incidence and/or severity of stroke. 3. Because the genesis of stroke is multifactorial, the prevention of stroke should not target one risk factor only. Combination therapies with drugs acting on different risk factors may be more effective in the prevention of stroke.

引用

页码：265 / 271

页数：7

共 68 条

[51] Depressive symptoms and risk of stroke - The Framingham Study [J].

Salaycik, Kimberly J. ;

Kelly-Hayes, Margaret ;

Beiser, Alexa ;

Nguyen, Anh-Hoa ;

Brady, Stephen M. ;

Kase, Carlos S. ;

Wolf, Philip A. .

STROKE, 2007, 38 (01) :16-21

[52] Role of oestrogen in the central regulation of autonomic function [J].

Saleh, T. M. ;

Connell, B. J. .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2007, 34 (09) :827-832

[53] Arterial baroreflex function determines the survival time in lipopolysaccharide-induced shock in rats [J].

Shen, FM ;

Guan, YF ;

Xie, HH ;

Su, DF .

SHOCK, 2004, 21 (06) :556-560

[54] Ketanserin-induced baroreflex enhancement in spontaneously hypertensive rats depends on central 5-HT2A receptors [J].

Shen, Fu-Ming ;

Wang, Jin ;

Ni, Can-Rong ;

Yu, Jian-Guang ;

Wang, Wei-Zhong ;

Su, Ding-Feng .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2007, 34 (08) :702-707

[55] Increased susceptibility of ventricular arrhythmias to aconitine in anaesthetized rats is attributed to the inhibition of baroreflex [J].

Shu, H ;

Yi-Ming, W ;

Xu, LP ;

Miao, CY ;

Su, DF .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2004, 31 (04) :249-253

[56] Cardiovascular and cancer morbidity and mortality and sudden cardiac death in postmenopausal women on oestrogen replacement therapy (ERT) [J].

Sourander, L ;

Rajala, T ;

Räihä, I ;

Mäkinen, J ;

Erkkola, R ;

Helenius, H .

LANCET, 1998, 352 (9145) :1965-1969

[57] Relative value of inflammatory, hemostatic, and rheological factors for incident myocardial infarction and stroke - The Edinburgh Artery Study [J].

Tzoulaki, Ioanna ;

Murray, Gordon D. ;

Lee, Amanda J. ;

Rumley, Ann ;

Lowe, Gordon D. O. ;

Fowkes, F. Gerald R. .

CIRCULATION, 2007, 115 (16) :2119-2127

[58] Efficacy of folic acid supplementation in stroke prevention: a meta-analysis [J].

Wang, Xiaobin ;

Qin, Xianhui ;

Demirtas, Hakan ;

Li, Jianping ;

Mao, Guangyun ;

Huo, Yong ;

Sun, Ningling ;

Liu, Lisheng ;

Xu, Xiping .

LANCET, 2007, 369 (9576) :1876-1882

[59] Effect of estrogen plus progestin on stroke in postmenopausal women - The Women's Health Initiative: A randomized trial [J].

Wassertheil-Smoller, S ;

Hendrix, SL ;

Limacher, M ;

Heiss, G ;

Kooperberg, C ;

Baird, A ;

Kotchen, T ;

Curb, JD ;

Black, H ;

Rossouw, JE ;

Aragaki, A ;

Safford, M ;

Stein, E ;

Laowattana, S ;

Mysiw, WJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (20) :2673-2684

[60] Associations of proinflammatory cytokines with the risk of recurrent stroke [J].

Welsh, Paul ;

Lowe, Gordon D. O. ;

Chalmers, John ;

Campbell, Duncan J. ;

Rumley, Ann ;

Neal, Bruce C. ;

MacMahon, Stephen W. ;

Woodward, Mark .

STROKE, 2008, 39 (08) :2226-2230

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