New strategies for the prevention of stroke

被引：11

作者：

Liu, Ai-Jun ^{[1
]}

Guo, Jin-Min ^{[1
]}

Xia, Weiliang ^{[2
]}

Su, Ding-Feng ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Pharmacol, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai 200030, Peoples R China

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2010年 / 37卷 / 02期

基金：

中国国家自然科学基金;

关键词：

arterial baroreflex; folic acid; hypertension; pro-inflammatory factor; risk factor; stroke prevention; C-REACTIVE PROTEIN; ARTERIAL BAROREFLEX FUNCTION; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; ISCHEMIC-STROKE; FOLIC-ACID; VITAMIN-D; POSTMENOPAUSAL WOMEN; RISK-FACTORS;

D O I：

10.1111/j.1440-1681.2009.05230.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Stroke is a major cause of disability and death worldwide. It is preferable to prevent stroke rather than to treat it and, for the prevention of stroke, all risk factors relating to stroke need to be understood. The present paper reviews potential new strategies for the prevention of stroke based on findings of new risk factors, as well as classical risk factors. 2. Recently, new risk factors related to stroke were reported, including dysfunction of the arterial baroreflex, pro-inflammatory cytokines, vitamins and hormone deficiency. Correspondingly, therapies targeting these risk factors where shown to significantly reduce the incidence and/or severity of stroke. 3. Because the genesis of stroke is multifactorial, the prevention of stroke should not target one risk factor only. Combination therapies with drugs acting on different risk factors may be more effective in the prevention of stroke.

引用

页码：265 / 271

页数：7

共 68 条

[21] Cigarette smoking and risk of stroke in the Chinese adult population [J].

Kelly, Tanika N. ;

Gu, Dongfeng ;

Chen, Jing ;

Huang, Jian-feng ;

Chen, Ji-chun ;

Duan, Xiufang ;

Wu, Xigui ;

Chen, Chung-Shiuan ;

He, Jiang .

STROKE, 2008, 39 (06) :1688-1693

[22] Lipid levels and the risk of ischemic stroke in women [J].

Kurth, T. ;

Everett, B. M. ;

Buring, J. E. ;

Kase, C. S. ;

Ridker, P. M. ;

Gaziano, J. M. .

NEUROLOGY, 2007, 68 (08) :556-562

[23] Healthy lifestyle and the risk of stroke in women [J].

Kurth, Tobias ;

Moore, Steven C. ;

Gaziano, J. Michael ;

Kase, Carlos S. ;

Stampfer, Meir J. ;

Berger, Klaus ;

Buring, Julie E. .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (13) :1403-1409

[24]

La Rovere MT, 2001, CIRCULATION, V103, P2072

[25]

La Rovere MT, 1998, LANCET, V351, P478

[26] Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke [J].

Lemaitre, RN ;

Weiss, NS ;

Smith, NL ;

Psaty, BM ;

Lumley, T ;

Larson, EB ;

Heckbert, SR .

ARCHIVES OF INTERNAL MEDICINE, 2006, 166 (04) :399-404

[27] Non-genomic vascular actions of female sex hormones: Physiological implications and signalling pathways [J].

Leung, Susan W. S. ;

Teoh, Hwee ;

Keung, Wendy ;

Man, Ricky Y. K. .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2007, 34 (08) :822-826

[28] Effects of combination therapy with atenolol and amlodipine on blood pressure control and stroke prevention in stroke-prone spontaneously hypertensive rats [J].

Ling, Gang ;

Liu, Ai-jun ;

Shen, Fu-ming ;

Cai, Guo-jun ;

Liu, Jian-guo ;

Su, Ding-feng .

ACTA PHARMACOLOGICA SINICA, 2007, 28 (11) :1755-1760

[29] Arterial baroreflex function is an important determinant of acute cerebral ischemia in rats with middle cerebral artery occlusion [J].

Liu, Ai-Jun ;

Ling, Gang ;

Wu, Jian ;

Shen, Fu-Ming ;

Wang, Di-Song ;

Lin, Li-Li ;

Liu, Jian-Guo ;

Su, Ding-Feng .

LIFE SCIENCES, 2008, 83 (11-12) :388-393

[30] Arterial baroreflex - A novel target for preventing stroke in rat hypertension [J].

Liu, Ai-Jun ;

Ma, Xiu-Juan ;

Shen, Fu-Ming ;

Liu, Jian-Guo ;

Chen, Hong ;

Su, Ding-Feng .

STROKE, 2007, 38 (06) :1916-1923

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