Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to In Vivo Compatibility in a Murine Subdermal Implant Model

被引：15

作者：

Dargaville, Tim R. ^{[3
,4
,5
]}

Harkin, Damien G. ^{[1
,2
]}

Park, Jong-Ryul ^{[3
,4
,5
]}

Cavalcanti, Amanda ^{[3
,4
,5
]}

Bolle, Eleonore C. L. ^{[1
]}

Savi, Flavia Medeiros ^{[6
]}

Farrugia, Brooke L. ^{[7
]}

Monnery, Bryn D. ^{[7
]}

Bernhard, Yann ^{[7
]}

Van Guyse, Joachim F. R. ^{[7
]}

Podevyn, Annelore ^{[7
]}

Hoogenboom, Richard ^{[7
]}

机构：

[1] Queensland Univ Technol, Sci & Engn Fac, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia

[2] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia

[3] Queensland Univ Technol, Ctr Mat Sci, Brisbane, Qld 4000, Australia

[4] Queensland Univ Technol, Sci & Engn Fac, Sch Chem & Phys, Brisbane, Qld 4000, Australia

[5] Queensland Univ Technol, Sci & Engn Fac, Inst Hlth & Biomed Innovat, Brisbane, Qld 4000, Australia

[6] Univ Melbourne, Dept Biomed Engn, Melbourne, Vic 3010, Australia

[7] Univ Ghent, Ctr Macromol Chem CMaC, Dept Organ & Macromol Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

来源：

BIOMACROMOLECULES | 2021年 / 22卷 / 04期

关键词：

FOREIGN-BODY REACTION; POLY(2-OXAZOLINE)S; AMIDATION; NETWORKS;

D O I：

10.1021/acs.biomac.1c00046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) and the methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C(3)MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained by a simple waterin-oil gelation method using thiol-ene coupling and investigated the in vivo biocompatibility of these hydrogel spheres in a 28-day murine subdermal model. For comparison, hydrogel spheres prepared from poly(ethylene glycol) were also implanted. Both materials displayed mild, yet typical foreign body responses with little signs of fibrosis. This is the first report on the foreign body response of a poly(2-oxazoline) hydrogel, which paves the way for future investigations into how this highly tailorable class of materials can be used for implantable hydrogel devices.

引用

页码：1590 / 1599

页数：10

共 49 条

[1] Foreign body reaction to biomaterials [J].