The effects of lobeline on depression-like behavior and hippocampal cell proliferation following chronic stress in mice

被引:13
作者
Roni, Monzurul Amin [1 ]
Rahman, Shafiqur [1 ]
机构
[1] S Dakota State Univ, Coll Pharm, Dept Pharmaceut Sci, Brookings, SD 57007 USA
关键词
Nicotinic receptor; Major depression; Chronic stress; Lobeline; BDNF; Hippocampus; NEUROGENESIS; MECAMYLAMINE; EXPRESSION; RECEPTORS; NICOTINE; CREB; PHOSPHORYLATION; INCREASES; BINDING; ACID;
D O I
10.1016/j.neulet.2014.10.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have reported that brain nicotinic acetylcholine receptor (nAChR) ligand lobeline has antidepressant-like effects in mice. The present study examined the effects of lobeline on chronic unpredictable stress (CUS)-induced depression-like behavior, deficits in brain-derived neurotrophic factor (BDNF) expression and cell proliferation in the hippocampus. Adult C57BL/61 mice were exposed to CUS for 6 weeks. Lobeline (1 or 4 mg/kg, s.c.) or saline was administered once daily during the last 14 days of CUS. CUS-exposed mice showed increased immobility time in the FST compared to control. Pretreatment with lobeline (1 mg/kg) significantly reduced immobility time in the CUS-exposed mice. Twenty-four hour following lobeline or saline treatment, BDNF expression or cell proliferation was measured in the hippocampus using Western blotting and bromodeoxyuridine immunohistochemistry, respectively. Lobeline (1 mg/kg) treatment prevented CUS-induced reduction in BDNF expression and cell proliferation in the hippocampus. Overall, our findings suggest that antidepressant-like effects of lobeline could involve nAChR mediated signaling, BDNF expression, and/or hippocampal cell proliferation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:7 / 11
页数:5
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