Comparison between laparoscopically assisted myomectomy (LAM) and abdominal myomectomy (laparotomy), used in the management of women with intramural or subserous uterine fibroids up to 90 mm of maximum diameter. Seventy-five premenopausal women were prospectively enrolled in the study, managed by LAM (n = 48) or by laparotomy (n = 27) approach. The short-term outcomes were compared between the two groups. The patient characteristics were also analyzed. The mean (+/- SD) estimated blood loss was significantly less in the LAM procedure compared with laparotomy (246 +/- A 161 vs. 351 +/- A 219 ml, respectively, P = 0.03). Similarly, the operative time was shorter in the LAM modality compared with laparotomy (68 +/- A 21 vs. 83 +/- A 24 min, respectively, P = 0.01). Intraoperative and postoperative complications were not different between the two groups. The mean days of the bowel reactivity (1.04 +/- A 0.2) was faster (P < 0.0001), while the duration of hospitalization (1.2 +/- A 0.6) was shorter (P < 0.0001) in the LAM technique, when compared with abdominal myomectomy (1.8 +/- A 0.5 and 4.2 +/- A 0.8, respectively). In selected group of patients, LAM as minimally invasive approach is an attractive alternative to conventional laparotomic myomectomy, offering significant advantages.