Simultaneous Separation of Quinine and Its Diastereoisomer Quinidine by RP-HPLC

被引：0

作者：

Fegas, R. ^{[1
]}

Bensalem, A. ^{[1
]}

Bettache, Z. ^{[1
]}

Righezza, M. ^{[1
]}

机构：

[1] Ecole Normale Super, Dept Chem, Vieux Kouba, Alger, Algeria

来源：

ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 02期

关键词：

Symmetry column liquid chromatography; Quinine; Quinidine; Aqueous mobile phase modifier; Triethylamine; Acetic acid; CHIRAL STATIONARY-PHASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; STRONGLY BASIC COMPOUNDS; ENANTIOSELECTIVE HYDROGENATION; ACIDS; ENANTIOSEPARATION; MODIFIERS; CARBAMATE; COLUMNS; MALARIA;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reversed-phase high-performance liquid chromatography method was developed for separation of quinine and its diastereoisomer quinidine. The best separation vas performed on symmetry C(18) (150 x 4.6 id, particle size 3.5 mu m. Acetonitrile-water-triethylamine-acetic acid 9:90:0.25:0.75 (v/v/v/v) was used as a mobile phase with flow rate I mL/min. pH was adjusted to 3.03 with orthophosphoric acid. UV detection was performed at 254 nm. The validation of the method performance characteristics was established to be adequate for intended use. The evaluation of number of parameters such as selectivity, linearity was realized with validation manager logician VWR international GmbH, Germany.

引用

页码：1587 / 1590

页数：4

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