Copper-(II) Catalyzed N-Formylation and N-Acylation of Aromatic, Aliphatic, and Heterocyclic Amines and a Preventive Study in the C-N Cross Coupling of Amines with Aryl Halides

被引：41

作者：

Sonawane, Rahul B. ^{[1
]}

Rasal, Nishant K. ^{[1
]}

Bhange, Dattatraya S. ^{[1
]}

Jagtap, Sangeeta V. ^{[1
]}

机构：

[1] Savitribai Phule Pune Univ, Baburaoji Gholap Coll, Dept Chem, Pune 411027, Sangvi, India

来源：

CHEMCATCHEM | 2018年 / 10卷 / 17期

关键词：

1,2, 4-triazole; C-N cross coupling reaction; Cu-(II) catalyzed; N-acylation; N-formylation; SOLVENT-FREE CONDITIONS; HIGHLY EFFICIENT PROCEDURE; ROOM-TEMPERATURE; CARBON-DIOXIDE; ULTRASOUND-IRRADIATION; RECYCLABLE CATALYST; AEROBIC OXIDATION; AMMONIUM FORMATE; SECONDARY-AMINES; SULFURIC-ACID;

D O I：

10.1002/cctc.201800609

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A Cu-(II) catalyzed N-formylation and N-acylation of amines with moderate to excellent yields, using N, N-dimethyl formamide (DMF) and N, N-dimethyl acetamide (DMA) as a formyl and acylating sources in the presence of 1,2,4-triazole is reported. This novel, highly efficient and simple protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines. In addition, the conditions to prevent N-formylation and N-acylation impurities in the C-N cross coupling of amines and aryl halides are described typically when DMF and DMA are used as solvents, with various catalysts, ligands, and bases.

引用

页码：3907 / 3913

页数：7