Familial and sporadic Parkinson's disease usually display the same clinical features

被引：13

作者：

Carr, J ^{[1
]}

de la Fuente-Fernández, R ^{[1
]}

Schulzer, M ^{[1
]}

Mak, E ^{[1
]}

Calne, SM ^{[1
]}

Calne, DB ^{[1
]}

机构：

[1] Univ British Columbia, UBC Hosp, Vancouver Hosp & Hlth Sci Ctr, Pacific Parkinsons Res Ctr, Vancouver, BC V6T 2B5, Canada

来源：

PARKINSONISM & RELATED DISORDERS | 2003年 / 9卷 / 04期

关键词：

Parkinson's disease; familial; sporadic; genetic; JUVENILE PARKINSONISM;

D O I：

10.1016/S1353-8020(02)00048-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined the clinical features of familial (n = 26) and sporadic (n = 52) Parkinson's disease (PD) in patients presenting over the age of 40 years. Familial PD cases were tested for alpha-synuclein or parkin mutations as appropriate. No mutations were found in any of the families investigated. We found no between-group differences in the age at onset of PD, the pattern or severity of parkinsonian features, the dose of antiparkinsonian medications or treatment related complications. Cases of familial and sporadic PD in our cohort of patients display similar clinical features. This may suggest similar etiologies for both familial and sporadic PD. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：201 / 204

页数：4

共 17 条

[1] CRITERIA FOR DIAGNOSING PARKINSONS-DISEASE [J].

CALNE, DB ;

SNOW, BJ ;

LEE, C .

ANNALS OF NEUROLOGY, 1992, 32 :S125-S127

[2] FAMILIAL PARKINSONS-DISEASE - POSSIBLE ROLE OF ENVIRONMENTAL-FACTORS [J].

CALNE, S ;

SCHOENBERG, B ;

MARTIN, W ;

UITTI, RJ ;

SPENCER, P ;

CALNE, DB .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1987, 14 (03) :303-305

[3]

de la Fuente-Fernández R, 2000, ANN NEUROL, V48, P782, DOI 10.1002/1531-8249(200011)48:5<782::AID-ANA12>3.0.CO

[4]

2-E

[5] Evidence for environmental causation of Parkinson's disease [J].

de la Fuente-Fernández, R ;

Calne, DB .

PARKINSONISM & RELATED DISORDERS, 2002, 8 (04) :235-241

[6]

Fahn S, 1987, Recent Developments in Parkinson's Disease., P153, DOI DOI 10.2490/JJRMC.47.791

[7] Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism [J].

Kitada, T ;

Asakawa, S ;

Hattori, N ;

Matsumine, H ;

Yamamura, Y ;

Minoshima, S ;

Yokochi, M ;

Mizuno, Y ;

Shimizu, N .

NATURE, 1998, 392 (6676) :605-608

[8] A CLINICAL AND GENETIC-STUDY OF FAMILIAL PARKINSONS-DISEASE [J].

MARAGANORE, DM ;

HARDING, AE ;

MARSDEN, CD .

MOVEMENT DISORDERS, 1991, 6 (03) :205-211

[9] Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop [J].

McKeith, IG ;

Galasko, D ;

Kosaka, K ;

Perry, EK ;

Dickson, DW ;

Hansen, LA ;

Salmon, DP ;

Lowe, J ;

MIrra, SS ;

Byrne, EJ ;

Lennox, G ;

Quinn, NP ;

Edwardson, JA ;

Ince, PG ;

Bergeron, C ;

Burns, A ;

Miller, BL ;

Lovestone, S ;

Collerton, D ;

Jansen, ENH ;

Ballard, C ;

deVos, RAI ;

Wilcock, GK ;

Jellinger, KA ;

Perry, RH .

NEUROLOGY, 1996, 47 (05) :1113-1124

[10]

Morales B, 1990, Arch Neurobiol (Madr), V53, P171

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