Some aspects of endogenic intoxication evaluation in patients with acute dysentery

Aim. To evaluate endogenic intoxication in patients with acute dysentery (AD) by examination of substances of low and medium molecular mass (LM and MM) in different body media. Material and methods. 122 patients with acute dysentery were tested for LM and MM substances by M. Ya. Malakhova in plasm, red cells, urine in the course of the disease. Results. Concentration of LM and MM substances in patients with AD was much higher compared to healthy subjects in all the examined fluids at the height of the disease. In decline of clinical symptoms the studied concentrations diminished, in early convalescence the substances were at normal levels in red cells and urine being higher in plasm. Maximal changes of the LM and MM substances' concentrations were noted in a severe course of AD. Conclusion. In acute bacterial dysentery concentration of LM and MM substances. in blood plasm, red cells and urine depend on the period of the disease course and AD severity. This may indicate the degree of endogenic intoxication in these patients.