Immunology - Unmasking the killer's accomplice

被引：19

作者：

Colonna, M ^{[1
]}

机构：

[1] Basel Inst Immunol, CH-4005 Basel, Switzerland

来源：

NATURE | 1998年 / 391卷 / 6668期

关键词：

D O I：

10.1038/35515

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One way in which our immune system detects virally infected cells is by monitoring levels of class I major histocompatibility complex (MHC). In infected cells, class I expression is downregulated, acting as a signal to the natural killer (NK) cells to target that cell for destruction. But some class I homologues stimulate — rather than inhibit — the NK cells, and one group has now found out why. They have discovered a signal-transducing adaptor molecule called DAP12, which couples recognition of class I MHC to an activating signal-transduction pathway.

引用

页码：642 / 643

页数：2

共 14 条

[1] The human leukocyte antigen (HLA)-C-specific ''activatory'' or ''inhibitory'' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions [J].