An Improved Synthesis of Imidazo[4,5-b]pyridines and Imidazo[4,5-b]pyrazines by Palladium Catalyzed Amidation using Xantphos in a 1,4-Dioxane:tert-Amyl Alcohol Solvent System

被引：6

作者：

Rosenberg, Adam J. ^{[1
]}

Ahmed, Ijaz ^{[1
]}

Wilson, Robert J. ^{[1
]}

Williams, Theresa M. ^{[1
]}

Kaminsky, Lauren ^{[1
]}

Clark, Daniel A. ^{[1
]}

机构：

[1] Syracuse Univ, Dept Chem, Ctr Sci & Technol 1 014, Syracuse, NY 13244 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 16期

基金：

美国国家科学基金会;

关键词：

nitrogen heterocycles; P ligands; palladium; CROSS-COUPLING REACTIONS; ARYL HALIDES; C-N; ROOM-TEMPERATURE; AMINATION; CHLORIDES; LIGANDS; DEHALOGENATION; DERIVATIVES; INHIBITORS;

D O I：

10.1002/adsc.201400465

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein an improved protocol for the synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b] pyrazines using a palladium-catalyzed amidation that utilizes Xantphos as an ancillary phosphine ligand is reported. The use of a binary solvent system comprised of 1,4-dioxane and tert-amyl alcohol was crucial in eliminating unwanted by-products.

引用

页码：3465 / 3470

页数：6

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