Paving New Roads for CARs

被引：25

作者：

Hyrenius-Wittsten, Axel ^{[1
,2
]}

Roybal, Kole T. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[2] Parker Inst Canc Immunotherapy, San Francisco, CA 94129 USA

[3] Chan Zuckerberg Biohub, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 10期

基金：

瑞典研究理事会;

关键词：

CHIMERIC ANTIGEN RECEPTOR; MODIFIED T-CELLS; 4-1BB COSTIMULATION; LYMPHOCYTES; SUPERIOR; DOMAIN; SURVIVAL; IMMUNOTHERAPY; RECOGNITION; ACTIVATION;

D O I：

10.1016/j.trecan.2019.09.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor (CAR)-T cell therapy has had unprecedented impact in the treatment of hematological malignancies with few therapeutic options. However, it is clear that new strategies to enhance CAR-T cell function in solid tumors are needed to make these living drugs widely applicable. The roadblock in solid tumors has led to a surge in the development of strategies to enhance CAR-T cells through advanced receptor design, new tumor sensing mechanisms, coexpression of genes that improve T cell function or stimulate tumor immunity, and precise genome editing. Here we provide an overview of the current state of the art in CAR-T cell engineering and a framework for the development of next-generation immune cell therapies with synthetic biology.

引用

页码：583 / 592

页数：10

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