Fragile sites: Breaking up over a slowdown

被引：36

作者：

Cimprich, KA ^{[1
]}

机构：

[1] Stanford Univ, Dept Mol Pharmacol, Stanford, CA 94305 USA

来源：

CURRENT BIOLOGY | 2003年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0960-9822(03)00158-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Common fragile sites are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Recent data suggest that these sites depend on the checkpoint kinase ATR to maintain their stability.

引用

页码：R231 / R233

页数：3

共 15 条

[1]

Brown EJ, 2000, GENE DEV, V14, P397

[2] Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance [J].

Brown, EJ ;

Baltimore, D .

GENES & DEVELOPMENT, 2003, 17 (05) :615-628

[3] Checking that replication breakdown is not terminal [J].

Carr, AM .

SCIENCE, 2002, 297 (5581) :557-558

[4] ATR regulates fragile site stability [J].

Casper, AM ;

Nghiem, P ;

Arlt, MF ;

Glover, TW .

CELL, 2002, 111 (06) :779-789

[5] ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones [J].

Cha, RS ;

Kleckner, N .

SCIENCE, 2002, 297 (5581) :602-606

[6] Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts [J].

Guo, ZJ ;

Kumagai, A ;

Wang, SX ;

Dunphy, WG .

GENES & DEVELOPMENT, 2000, 14 (21) :2745-2756

[7] Xenopus ATR is a replication-dependent chromatin-binding protein required for the DMA replication checkpoint [J].

Hekmat-Nejad, M ;

You, ZS ;

Yee, MC ;

Newport, JW ;

Cimprich, KA .

CURRENT BIOLOGY, 2000, 10 (24) :1565-1573

[8] FRA3B and other common fragile sites:: The weakest links [J].

Huebner, K ;

Croce, CM .

NATURE REVIEWS CANCER, 2001, 1 (03) :214-221

[9]

Ingvarsson S, 1999, CANCER RES, V59, P2682

[10]

Mori M, 2001, CANCER RES, V61, P7379

← 1 2 →