Tuning morphology of sulfadiazine through phase transformation of two novel solvates

被引：4
作者：
Li, Peiyi [1 ]
Liu, Yu [1 ]
Li, Zhonghua [1 ]
Gong, Junbo [1 ,2 ]
Wu, Songgu [1 ,2 ]
机构：
[1] Tianjin Univ, Sch Chem Engn & Technol, State Key Lab Chem Engn, Tianjin 300072, Peoples R China
[2] Key Lab Modern Drug Delivery & High Efficiency Ti, Tianjin 300072, Peoples R China
来源：
JOURNAL OF CRYSTAL GROWTH | 2021年 / 562卷
基金：
中国博士后科学基金; 美国国家科学基金会;
关键词：
A1; Crystal structure; Crystal morphology; A2; Solvent-mediated transformation; B1; Solvate;
D O I：
10.1016/j.jcrysgro.2021.126087
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
Two new solvates of the widely used antibiotic sulfadiazine were found and fully characterized. The crystal structures of these two solvates were determined. Differences between various sulfadiazine forms were elucidated by analyzing intermolecular interactions, crystal packing modes and molecule conformations. In addition, the phase transformations between solvates and solvent-free form were investigated. The sulfadiazine solvates quickly transformed into solvent-free form in water. The obtained particles were aggregates but with welldefined shape. They maintained the morphology and size of the solvate crystals. The results indicated that solvates can be used as intermediates to regulate the morphology of solvent-free form product through rapid solvent-mediated phase transformation.
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页数：7
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