Amyloid-beta Targeted Therapeutic Approaches for Alzheimer's Disease: Long Road Ahead

被引：7

作者：

Dai, Yuxuan ^{[1
]}

Lei, Chenyi ^{[2
]}

Zhang, Zhenhao ^{[1
]}

Qi, Yan ^{[1
]}

Lao, Kejing ^{[1
]}

Gou, Xingchun ^{[1
]}

机构：

[1] Xian Med Univ, Academician Workstn Chen Zhi Nan Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Brain Disorders, Xian 710021, Peoples R China

[2] Xi An Jiao Tong Univ, Coll Pharm, Xian 710049, Peoples R China

来源：

CURRENT DRUG TARGETS | 2022年 / 23卷 / 11期

关键词：

Alzheimer's disease; amyloid beta; clinical research; immunotherapy; and drug development; neurodegenerative disorder; GAMMA-SECRETASE INHIBITOR; A-BETA; DOUBLE-BLIND; TRIAL; A-BETA-42; SAFETY; IMMUNOTHERAPY; RESVERATROL; PREVENTION; MECHANISM;

D O I：

10.2174/1389450123666220421124030

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline. The obvious pathological features of AD are still amyloid plaques and neurofibrillary tangles. Development of disease-modifying treatments for AD has been challenging, with almost all drugs aborted. The amyloid cascade concept has been questioned due to the failures of various amyloid-targeting prospects. Despite this, targeting amyloid-beta (A beta) active immunotherapy provided some positive results to support this hypothesis and clinical trials of these candidates are ongoing. In this review, we describe the latest advance in therapeutic strategies based on amyloidogenic processing and evaluate the pros and cons of each treatment strategy. We also highlight the current status of the hottest immunotherapy and discuss the future development direction.

引用

页码：1040 / 1056

页数：17

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