A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

被引：92

作者：

Cao, Shuhua ^{[1
,2
]}

Fan, Jiangli ^{[2
]}

Sun, Wen ^{[2
]}

Li, Fahui ^{[3
]}

Li, Kaoxue ^{[1
]}

Tai, Xishi ^{[1
]}

Peng, Xiaojun ^{[2
]}

机构：

[1] Weifang Univ, Coll Chem Chem & Environm Engn, 5147 Dongfeng St, Weifang 261061, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

[3] Weifang Med Univ, Sch Pharm, 7166 Baotong St, Weifang 261053, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期

基金：

美国国家科学基金会;

关键词：

PHOTODYNAMIC THERAPY; APOPTOSIS; NETWORK;

D O I：

10.1039/c9cc06040e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.

引用

页码：12956 / 12959

页数：4

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