The Impact of Microbiota on Brain and Behavior: Mechanisms & Therapeutic Potential

被引:235
作者
Borre, Yuliya E. [1 ]
Moloney, Rachel D. [1 ,2 ]
Clarke, Gerard [1 ,2 ]
Dinan, Timothy G. [2 ]
Cryan, John F. [3 ]
机构
[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Lab NeuroGastroenterol, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland
[3] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland
来源
MICROBIAL ENDOCRINOLOGY: THE MICROBIOTA-GUT-BRAIN AXIS IN HEALTH AND DISEASE | 2014年 / 817卷
关键词
IRRITABLE-BOWEL-SYNDROME; ANXIETY-LIKE BEHAVIOR; POSTMYOCARDIAL INFARCTION DEPRESSION; PROBIOTIC BIFIDOBACTERIUM-INFANTIS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; MATERNAL SEPARATION; NERVOUS-SYSTEM; FATTY-ACIDS; GASTROINTESTINAL MICROBIOTA;
D O I
10.1007/978-1-4939-0897-4_17
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is increasing evidence that host-microbe interactions play a key role in maintaining homeostasis. Alterations in gut microbial composition is associated with marked changes in behaviors relevant to mood, pain and cognition, establishing the critical importance of the bi-directional pathway of communication between the microbiota and the brain in health and disease. Dysfunction of the microbiome-brain-gut axis has been implicated in stress-related disorders such as depression, anxiety and irritable bowel syndrome and neurodevelopmental disorders such as autism. Bacterial colonization of the gut is central to postnatal development and maturation of key systems that have the capacity to influence central nervous system (CNS) programming and signaling, including the immune and endocrine systems. Moreover, there is now expanding evidence for the view that enteric microbiota plays a role in early programming and later response to acute and chronic stress. This view is supported by studies in germ-free mice and in animals exposed to pathogenic bacterial infections, probiotic agents or antibiotics. Although communication between gut microbiota and the CNS are not fully Delucidated, neural, hormonal, immune and metabolic pathways have been suggested. Thus, the concept of a microbiome-brain-gut axis is emerging, suggesting microbiota-modulating strategies may be a tractable therapeutic approach for developing novel treatments for CNS disorders.
引用
收藏
页码:373 / 403
页数:31
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