CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

被引：1183

作者：

Teicher, Beverly A. ^{[1
]}

Fricker, Simon P. ^{[1
]}

机构：

[1] Genzyme Corp, Framingham, MA 01701 USA

来源：

CLINICAL CANCER RESEARCH | 2010年 / 16卷 / 11期

关键词：

CHEMOKINE RECEPTOR CXCR4; HEMATOPOIETIC PROGENITOR CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; FOCAL ADHESION PROTEINS; TYROSINE PHOSPHORYLATION; T-LYMPHOCYTES; TUMOR-GROWTH; IN-VIVO; AMD3100; ANTAGONIST;

D O I：

10.1158/1078-0432.CCR-09-2329

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. CXCR4 is expressed on multiple cell types including lymphocytes, hematopoietic stem cells, endothelial and epithelial cells, and cancer cells. The CXCL12/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival. This pathway is a target for therapeutics that can block the CXCL12/CXCR4 interaction or inhibit downstream intracellular signaling. Clin Cancer Res; 16(11); 2927-31. (C) 2010 AACR.

引用

收藏

页码：2927 / 2931

页数：5

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