pH-sensitive chitosan nanoparticles loaded with dolutegravir as milk and food admixture for paediatric anti-HIV therapy

被引：28

作者：

Dharshini, K. Priya ^{[1
]}

Fang, Hao ^{[2
,3
]}

Devi, D. Ramya ^{[1
]}

Yang, Jin-Xuan ^{[2
,3
]}

Luo, Rong-Hua ^{[2
]}

Zheng, Yong-Tang ^{[2
]}

Brzezinski, Marek ^{[4
]}

Hari, Vedha B. N. ^{[1
]}

机构：

[1] SASTRA Deemed To Be Univ, Pharmaceut Technol Lab, ASK 2, Lab 214, Thanjavur 613401, Tamil Nadu, India

[2] Chinese Acad Sci, Key Lab Anim Models & Human Dis Mech, Key Lab Bioact Peptides Yunnan Prov, Kunming Inst Zool, Kunming 650223, Yunnan, Peoples R China

[3] Yunnan Univ Chinese Med, Coll Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China

[4] Polish Acad Sci, Ctr Mol & Macromol Studies Lodz, Sienkiewicza 112, PL-90363 Lodz, Poland

来源：

CARBOHYDRATE POLYMERS | 2021年 / 256卷

关键词：

Biopolymer; Chitosan; Dolutegravir; Spray drying; Portunus sanguinolentus; Nanoparticle; CONTROLLED DRUG-DELIVERY; PHYSICOCHEMICAL PROPERTIES; IN-VITRO; RELEASE; CHITIN; DEACETYLATION; FORMULATIONS; ACETATE; NMR;

D O I：

10.1016/j.carbpol.2020.117440

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present study aims to develop Chitosan-based polymeric nanoparticles of anti-HIV drug Dolutegravir, to aid appropriate dose adjustment and ease of oral administration as milk and food admixture for children. The isolated Chitosan from the crab shell species Portunus Sanguinolentus has been characterized for their physicochemical properties. Nanoparticles were developed with varying ratio of drug: Chitosan and assessed for particle size (140-548 nm), zeta potential (+26.1 mV) with a maximum of 75 % drug content. Nanoparticles exhibited improved stability and drug release in the 0.1 N HCl medium compared to pure drug. The MTT assay and the Syncytia inhibition assay in C8166 (T-lymphatic cell line) infected with HIVIIIB viral strain, which showed better therapeutic efficiency and lesser cytotoxicity compared to the pure drug. In consonance with the data obtained, the use of chitosan from a novel source for drug delivery carrier has opened exceptional prospects for delivering drugs efficiently to paediatrics

引用

页数：12

共 61 条

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