共 58 条
Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway
被引:33
作者:

Liu, Yi
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Huang, Jie
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Zheng, Xian
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Yang, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Ding, Yan
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Fang, Tongyong
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Zhang, Yuyun
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Wang, Shuaishuai
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Zhang, Xiaofei
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Luo, Xuan
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Guo, Anlei
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Newell, Kelly A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wollongong, Fac Sci Med & Hlth, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Yu, Yinghua
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Immun & Metab, Xuzhou 221004, Peoples R China
Univ Wollongong, Fac Sci Med & Hlth, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China

Huang, Xu-Feng
论文数: 0 引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Immun & Metab, Xuzhou 221004, Peoples R China
Univ Wollongong, Fac Sci Med & Hlth, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China
机构:
[1] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou, Jiangsu, Peoples R China
[2] Xuzhou Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Immun & Metab, Xuzhou 221004, Peoples R China
[3] Univ Wollongong, Fac Sci Med & Hlth, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia
来源:
SCIENTIFIC REPORTS
|
2017年
/
7卷
基金:
中国国家自然科学基金;
关键词:
PC12 CELL APOPTOSIS;
DIABETIC ENCEPHALOPATHY;
OXIDATIVE STRESS;
KAPPA-B;
MTOR;
HIPPOCAMPUS;
DYSFUNCTION;
PROTECTS;
DEFICITS;
BRAIN;
D O I:
10.1038/s41598-017-08204-6
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Methylglyoxal (MG) accumulation has been observed in human cerebrospinal fluid and body tissues under hyperglycaemic conditions. Recent research has demonstrated that MG-induces neuronal cell apoptosis, which promotes the development of diabetic encephalopathy. Our previous animal study has shown that luteolin, a natural flavonoid, attenuates diabetes-associated cognitive dysfunction. To further explore the neuroprotective properties of luteolin, we investigated the inhibitive effect of luteolin on MG-induced apoptosis in PC12 neuronal cells. We found that MG inhibited cell viability in a dose-dependent manner and induced apoptosis in PC12 cells. Pretreatment with Luteolin significantly elevated cell viability, reduced MG-induced apoptosis, inhibited the activation of the mTOR/4E-BP1 signaling pathway, and decreased pro-apoptotic proteins, Bax, Cytochrome C as well as caspase-3. Furthermore, we found that pretreatment with the mTOR inhibitor, rapamycin, significantly reduced the expression of the pro-apoptotic protein Bax. Therefore, these observations unambiguously suggest that the inhibitive effect of Luteolin against MG-induced apoptosis in PC12 cells is associated with inhibition of the mTOR/4E-BP1 signaling pathway.
引用
收藏
页数:11
相关论文
共 58 条
- [1] Protective role of luteolin on the status of lipid peroxidation and antioxidant defense against azoxymethane-induced experimental colon carcinogenesis[J]. BIOMEDICINE & PHARMACOTHERAPY, 2008, 62 (09) : 590 - 597Ashokkumar, Pandurangan论文数: 0 引用数: 0 h-index: 0机构: Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India论文数: 引用数: h-index:机构:
- [2] Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature[J]. JOURNAL OF NEUROSCIENCE, 2014, 34 (23) : 7988 - 7998Caccamo, Antonella论文数: 0 引用数: 0 h-index: 0机构: Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA Univ Catania, Dept Biol Geol & Environm Sci, I-95125 Catania, Italy Banner Sun Hlth Res Inst, Sun City, AZ 85351 USADe Pinto, Vito论文数: 0 引用数: 0 h-index: 0机构: Univ Catania, Dept Biol Geol & Environm Sci, I-95125 Catania, Italy Banner Sun Hlth Res Inst, Sun City, AZ 85351 USAMessina, Angela论文数: 0 引用数: 0 h-index: 0机构: Univ Catania, Dept Biol Geol & Environm Sci, I-95125 Catania, Italy Banner Sun Hlth Res Inst, Sun City, AZ 85351 USABranca, Caterina论文数: 0 引用数: 0 h-index: 0机构: Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy Banner Sun Hlth Res Inst, Sun City, AZ 85351 USA论文数: 引用数: h-index:机构:
- [3] Superoxide activates mTOR-eIF4E-Bax route to induce enhanced apoptosis in leukemic cells[J]. APOPTOSIS, 2014, 19 (01) : 135 - 148Chaudhuri, Jaydeep论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaChowdhury, Avik Acharya论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaBiswas, Nabendu论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaManna, Anirban论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaChatterjee, Saurav论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Chem, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaMukherjee, Tulika论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Chem, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaChaudhuri, Utpal论文数: 0 引用数: 0 h-index: 0机构: Coll Med, Inst Hematol & Transfus Med, Kolkata, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaJaisankar, Parasuraman论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Chem, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, IndiaBandyopadhyay, Santu论文数: 0 引用数: 0 h-index: 0机构: IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India IICB, CSIR, Div Canc Biol & Inflammatory Disorder, Kolkata 700032, India
- [4] Luteolin suppresses cisplatin-induced apoptosis in auditory cells: Possible mediation through induction of heme oxygenase-1 expression[J]. JOURNAL OF MEDICINAL FOOD, 2008, 11 (02) : 230 - 236论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Gao, Shang Shang论文数: 0 引用数: 0 h-index: 0机构: Wonkwang Univ, Sch Med, Dept Biochem, Iksan 570749, Chonbuk, South Korea Wonkwang Univ, Vestibulocochlear Res Ctr, Iksan, Chonbuk, South Korea Wonkwang Univ, Sch Med, Dept Biochem, Iksan 570749, Chonbuk, South KoreaKwon, Dae Young论文数: 0 引用数: 0 h-index: 0机构: Korea Food Res Inst, Funct Food Res Ctr, Songnam, Gyungki Do, South Korea Wonkwang Univ, Sch Med, Dept Biochem, Iksan 570749, Chonbuk, South KoreaKim, Bok-Ryang论文数: 0 引用数: 0 h-index: 0机构: Wonkwang Univ, Sch Med, Dept Biochem, Iksan 570749, Chonbuk, South Korea Wonkwang Univ, Vestibulocochlear Res Ctr, Iksan, Chonbuk, South Korea Wonkwang Univ, Sch Med, Dept Biochem, Iksan 570749, Chonbuk, South Korea
- [5] Methylglyoxal Causes Cell Death in Neural Progenitor Cells and Impairs Adult Hippocampal Neurogenesis[J]. NEUROTOXICITY RESEARCH, 2016, 29 (03) : 419 - 431Chun, Hye Jeong论文数: 0 引用数: 0 h-index: 0机构: Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent, Coll Pharm, Dept Pharm, Busan 609735, South Korea Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent, Coll Pharm, Dept Pharm, Busan 609735, South KoreaLee, Yujeong论文数: 0 引用数: 0 h-index: 0机构: Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent, Coll Pharm, Dept Pharm, Busan 609735, South Korea Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent, Coll Pharm, Dept Pharm, Busan 609735, South Korea论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:
- [6] Caspases 3 and 9 send a pro-apoptotic signal from synapse to cell body in olfactory receptor neurons[J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (18) : 7099 - 7109Cowan, CM论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaThai, J论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaKrajewski, S论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaReed, JC论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaNicholson, DW论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaKaufmann, SH论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, CanadaRoskams, AJ论文数: 0 引用数: 0 h-index: 0机构: Univ British Columbia, Dept Psychiat, Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada
- [7] Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype[J]. JOURNAL OF NEUROINFLAMMATION, 2010, 7论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Kraus, Dominik论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, GermanyHlawatsch, Julia论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, GermanyWalczak, Yana论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, GermanyMoehle, Christoph论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Ctr Excellence Fluorescent Bioanalyt, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, GermanyFuchshofer, Rudolf论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Inst Human Anat & Embryol, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, GermanyLangmann, Thomas论文数: 0 引用数: 0 h-index: 0机构: Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany Univ Regensburg, Inst Human Genet, D-93053 Regensburg, Germany
- [8] PI3K/Akt and mTOR/p70S6K pathways mediate neuroprotectin D1-induced retinal pigment epithelial cell survival during oxidative stress-induced apoptosis[J]. EXPERIMENTAL EYE RESEARCH, 2010, 90 (06) : 718 - 725Faghiri, Zahra论文数: 0 引用数: 0 h-index: 0机构: Louisiana State Univ, Neurosci Ctr Excellence, Hlth Sci Ctr, New Orleans, LA 70112 USA Louisiana State Univ, Neurosci Ctr Excellence, Hlth Sci Ctr, New Orleans, LA 70112 USABazan, Nicolas G.论文数: 0 引用数: 0 h-index: 0机构: Louisiana State Univ, Neurosci Ctr Excellence, Hlth Sci Ctr, New Orleans, LA 70112 USA Louisiana State Univ, Neurosci Ctr Excellence, Hlth Sci Ctr, New Orleans, LA 70112 USA
- [9] Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone[J]. ACTA OPHTHALMOLOGICA, 2009, 87 (05) : 498 - 500Fosmark, Dag S.论文数: 0 引用数: 0 h-index: 0机构: Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, Norway Aker & Ulleval Univ Hosp, Diabet Res Ctr, Oslo, Norway Inst Aviat Med, Oslo, Norway Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwayBerg, Jens P.论文数: 0 引用数: 0 h-index: 0机构: Aker Univ Hosp, Hormone Lab, Oslo, Norway Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwayJensen, Aase-Brith论文数: 0 引用数: 0 h-index: 0机构: Aker Univ Hosp, Hormone Lab, Oslo, Norway Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwaySandvik, Leiv论文数: 0 引用数: 0 h-index: 0机构: Ullevaal Univ Hosp, Clin Res Ctr, Oslo, Norway Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwayAgardh, Elisabet论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp MAS, Dept Clin Sci, Malmo, Sweden Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwayAgardh, Carl-David论文数: 0 引用数: 0 h-index: 0机构: Univ Hosp MAS, Dept Clin Sci, Malmo, Sweden Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, NorwayHanssen, Kristian F.论文数: 0 引用数: 0 h-index: 0机构: Inst Aviat Med, Oslo, Norway Aker Univ Hosp, Dept Endocrinol, Oslo, Norway Ullevaal Univ Hosp, Dept Ophthalmol, N-0450 Oslo, Norway
- [10] Lipid raft connection between extrinsic and intrinsic apoptotic pathways[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 380 (04) : 780 - 784论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Mollinedo, Faustino论文数: 0 引用数: 0 h-index: 0机构: Univ Salamanca, Ctr Invest Canc, Inst Biol Mol & Celular Canc, CSIC, E-37007 Salamanca, Spain Univ Salamanca, Ctr Invest Canc, Inst Biol Mol & Celular Canc, CSIC, E-37007 Salamanca, Spain