Antibody arrays - An emerging tool in cancer proteomics

被引：50
作者：
Kopf, Eliezer [1 ]
Zharhary, Dorit [1 ]
机构：
[1] Sigma Aldrich Israel Ltd, IL-76100 Rehovot, Israel
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2007年 / 39卷 / 7-8期
关键词：
antibody array; proteomics; protein profiling; biomarkers; cancer;
D O I：
10.1016/j.biocel.2007.04.029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is a result of complex changes that occur in normal cells as they transform to become malignant and further when they become metastatic. These changes are not a consequence of a single protein but rather involve multiple proteins that function in pathways and networks. Thus, profiling cancer-associated changes requires simultaneous measurement of many proteins in a single sample. Identifying these changes may lead to the discovery of cancer-associated biomarkers that may assist in diagnosis, prognosis, patient monitoring and possibly for therapeutic purposes. Antibody arrays are a relatively new technology that enables one to perform multiplex high-throughput protein expression profiling. This review describes current technologies in antibody array and assay design, and presents a survey of the current literature on the use of these arrays in cancer research. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1305 / 1317
页数：13
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