Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae

被引：135

作者：

Pan, XW ^{[1
]}

Harashima, T

Heitman, J

机构：

[1] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Genet, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[3] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Microbiol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Howard Hughes Med Inst, Dept Med, Durham, NC 27710 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2000年 / 3卷 / 06期

关键词：

D O I：

10.1016/S1369-5274(00)00142-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous pseudohyphal growth. At least two signaling pathways regulate filamentation. One involves components of the MAP kinase cascade that also regulates mating of haploid cells. The second involves a nutrient-sensing G-protein-coupled receptor that signals via an unusual G(alpha) protein, cAMP and protein kinase A. Recent studies reveal crosstalk between these pathways during pseudohyphal growth. Related MAP kinase and cAMP pathways regulate filamentation and virulence of human and plant fungal pathogens, and represent novel targets for antifungal drug design.

引用

页码：567 / 572

页数：6

共 56 条

[1] Regulation of G2/M progression by the STE mitogen-activated protein kinase pathway in budding yeast filamentous growth [J].

Ahn, SH ;

Acurio, A ;

Kron, SJ .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (10) :3301-3316

[2] Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae [J].

Ansari, K ;

Martin, S ;

Farkasovsky, M ;

Ehbrecht, IM ;

Küntzel, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :30052-30058

[3] Differential regulation of transcription: Repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins [J].

Bardwell, L ;

Cook, JG ;

Zhu-Shimoni, JX ;

Voora, D ;

Thorner, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15400-15405

[4]

BLACKETER MJ, 1995, GENETICS, V140, P1259

[5] REGULATION OF DIMORPHISM IN SACCHAROMYCES-CEREVISIAE - INVOLVEMENT OF THE NOVEL PROTEIN-KINASE HOMOLOG ELM1P AND PROTEIN PHOSPHATASE 2A [J].

BLACKETER, MJ ;

KOEHLER, CM ;

COATS, SG ;

MYERS, AM ;

MADAULE, P .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (09) :5567-5581

[6] Ash1, a daughter cell-specific protein, is required for pseudohyphal growth of Saccharomyces cerevisiae [J].

Chandarlapaty, S ;

Errede, B .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :2884-2891

[7] Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae [J].

Colombo, S ;

Ma, PS ;

Cauwenberg, L ;

Winderickx, J ;

Crauwels, M ;

Teunissen, A ;

Nauwelaers, D ;

de Winde, JH ;

Gorwa, MF ;

Colavizza, D ;

Thevelein, JM .

EMBO JOURNAL, 1998, 17 (12) :3326-3341

[8] Inhibitory and activating functions for MAPK Kss1 in the S-cerevisiae filamentous-growth signalling pathway [J].

Cook, JG ;

Bardwell, L ;

Thorner, J .

NATURE, 1997, 390 (6655) :85-88

[9] Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae [J].

Cook, JG ;

Bardwell, L ;

Kron, SJ ;

Thorner, J .

GENES & DEVELOPMENT, 1996, 10 (22) :2831-2848

[10]

Davenport KD, 1999, GENETICS, V153, P1091

← 1 2 3 4 5 6 →